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Effects and Its Mechanism of Endurance Exercise on Atherosclerosis Formation Fed with High Fat Diet
XU Si-mao, MO Wei-bin, LIU Wei-guo
Journal of Guangxi Normal University(Natural Science Edition). 2014, 32 (3):
125-132.
To explore the effects and its mechanism of different intensity exercise on atherosclerosis (AS) formation in Rats fed with high fat diet for short cycle,50 rown male SD rats were randomly divided into normal control group (group N),high fat diet group (group H),high intensity exercise group (group Hh),moderate intensity exercise group (group Hm), and low intensity exercise group (group Hl). Observe whether the thoracic aorta AS lesions existed in rats, analyze AS incidence and AS plaque area, and detect serum TC,TG,LDL-C, HDL-C and SOD, MDA and ox-LDL indexs.The results show that serum TC, LDL-C,MDA and ox-LDL levels increased significantly in rats fed with high fat diet for six weeks,and AS incidence increased significantly, comparing with group H. TC and LDL-C levels decreased significantly in group Hh,group Hm and group Hl,HDL-C level increased significantly in group Hl.In Group Hh, group Hm, group Hl,MDA levels were significantly lower than those of group H,but SOD activity was not increased apparently in group Hl.In group Hl,ox-LDL level and AS plaque area percentage were significantly lower than that of group H. It draw a conclusion that high fat diet for 6 weeks causing dyslipidemia,free radical metabolism increased,and the increase in LDL oxidation modification led to mild AS. To regulating blood fat, effect of low intensity exercise is the best,so low intensity exercise can control the reaction of LDL oxidative modification and strengthen the role of anti AS formation.
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