Journal of Guangxi Normal University(Natural Science Edition) ›› 2026, Vol. 44 ›› Issue (3): 204-213.doi: 10.16088/j.issn.1001-6600.2025062001

• Medicinal Resources Research • Previous Articles     Next Articles

Chemical Components and Glucose Uptake Activity From Ethyl Acetate Fraction of Ferula conocaula Korovin

LIAO Siyi1, CHU Moyan1, PANG Kejian2, LU Rumei3, Ajierguli Maimaiti4, LIN Qinxiong1*, YANG Xinzhou1,4*   

  1. 1. School of Pharmacy, South-Central Minzu University, Wuhan Hubei 430074, China;
    2. School of Pharmacy, Shihezi University, Shihezi Xinjiang 832003, China;
    3. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China;
    4. Key Laboratory of Xinjiang Hetian Characteristic Chinese Traditional Medicine Research (Xinjiang Hetian College), Hetian Xinjiang 848000, China
  • Received:2025-06-20 Revised:2025-09-03 Online:2026-05-05 Published:2026-05-13

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Abstract: Using a combination of multiple column chromatography and high-performance liquid chromatography separation techniques, the ethyl acetate fraction of Ferula conocaula Korovin was isolated and purified. Modern spectroscopic methods were employed to structurally characterize the obtained monomeric compounds. This study successfully isolated 19 monomeric compounds from the ethyl acetate fraction of Ferula conocaula Korovin. including 4 polyphenolic monomers, 14 caffeoylquinic acid monomers, and 1 flavonoid monomer. They are identified as caffeic acid (1), caffeic acid methyl ester (2), 3,4-dihydroxybenzaldehyde (3), 5-O-caffeoylquinic acid (4), 1-O-caffeoylquinic acid (5), chlorgenic acid (6), methyl chlorogenate (7), 3-O-trans-feruloylquinic acid (8), methyl 5-O-p-coumaroylquinic acid (9), methyl 5-O-feruloylquinate (10), acanthopacid G (11), 1-(3,4-dihydroxycinnamoyl) cyclopentene-2,3-diol (12), 4,5-di-O-caffeoylquinic acid 1-methyl ether (13), 4-O-caffeoyl-5-O-feruloylquinic acid methyl ester (14), methy 3,5-dicaffeoylquinate (15), 1,5-di-O-caffeoylquinic acid (16), 1,3-di-O-caffeoylquinic acid (17), methyl 4-O-E- feruloyl 5-O-E-caffeoyl-quinate (18), and luteolin 7-O-glucoside (19). It is worth nothing that compounds 1-6 and 8-19 were isolated from this plant for the first time. Glucose uptake activity assay experiments showed that compounds 7, 13, 15, and 16 had strong blood glucose lowering effects.

Key words: Ferula conocaula Korovin, chemical composition, caffeoylquinic acid, polyphenol, glucose uptake activity, detect

CLC Number:  R284.1
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