Journal of Guangxi Normal University(Natural Science Edition) ›› 2022, Vol. 40 ›› Issue (5): 271-285.doi: 10.16088/j.issn.1001-6600.2022012804

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Research Advances in Ultrasound Mediated Drug Delivery

WU Ruiqi, LIANG Xiaolong*   

  1. Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China
  • Received:2022-01-28 Revised:2022-04-20 Online:2022-09-25 Published:2022-10-18

Abstract: How to achieve efficient and targeted drug delivery is a current research hotspot. Ultrasound has the advantages of non-invasiveness, non-radiation, simple operation and low price. Clinical diagnosis uses the principles of reflection, refraction and diffraction of ultrasound. Attributed to its mechanical and thermal effects, ultrasound is also an efficient exogenous stimulation method for controlling drug release, which can improve the permeability of diseased tissues and cell membranes, and promote the uptake of drugs by cells. On this basis, the ultrasound mediated drug delivery has become an efficient and noninvasive delivery technology. The targeted and quantitative release of drugs can be realized by irradiating the tumor area with ultrasound, so as to increase the local drug concentration and thus improve the curative effect. Ultrasound combined with various carriers, such as ultrasonic microbubbles, liposomes and so on, has great clinical translation value in drug targeted delivery. This article will review ultrasound-enhanced drug delivery mechanism, ultrasound responsive carriers, the effect of ultrasound-enhanced drug delivery and its clinical application prospects.

Key words: ultrasound, drug delivery, micro-nano materials, ultrasound molecular imaging, targeted therapy, clinical application

CLC Number: 

  • R943
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