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Review on the Constituents and Pharmacological Activities of Cyclocarya paliurus
LI Jun, LIANG Xiaoqin, CHANG Yanling, HUANG Yan, PAN Liwei
Journal of Guangxi Normal University(Natural Science Edition). 2022, 40 (5):
227-252.
DOI: 10.16088/j.issn.1001-6600.2022030804
Cyclocarya paliurus (Batal) Iljinskaja, belonging to the genus Cyclocarya (Juglandaceae), consists only one species distributed in south China. C. paliurus leaves are used in traditional medicine for a long history. It contains the inorganic constant and trace components required by the human body, and it is a selenium-rich plant product. More than 240 compounds, including dammarane triterpenoids, oleanane triterpenoids, ursane triterpenoids, lupinane triterpenoids, flavonoids, isosclerones, phenolic derivatives, and polysaccharides, etc, have been separated from C. paliurus. Among them, 3,4-seco-dammarane triterpenoids are the most abundant and the most characteristic. Furthermore, the extracts and compounds from C. paliurus have been found to exert various pharmacological activities, such as anti-hyperglycemic, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, cytotoxic activities. Although great breakthroughs during the past 30 years years have been made in the research of the pharmacology and constituents of C. paliurus, the research and development of drugs related to C. paliurus has lagged behind seriously. The systematic and in-depth research is still needed in the toxicity and development of C. paliurus. The present review summarizes the constituents and pharmacological activity of C. paliurus to provide reference for further research, development and utilization of this plant.
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