Journal of Guangxi Normal University(Natural Science Edition) ›› 2022, Vol. 40 ›› Issue (5): 300-306.doi: 10.16088/j.issn.1001-6600.2022031008

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Stimulus-Responsive Nanozymes and Their in Situ Catalytic Enhancement of Tumor Therapy

LIANG Jiawei1,2,3, SUN Wanying1,2,3, LUO-LIU Ruiqi1,2,3, JIANG Bangping1,2,3, SHEN Xingcan1,2,3*   

  1. 1. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi, 541004, China;
    2. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China, Guilin Guangxi 541004, China;
    3. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University), Guilin Guangxi 541004, China
  • Received:2022-03-10 Revised:2022-04-20 Online:2022-09-25 Published:2022-10-18

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Abstract: Nanozyme is a kind of nanomaterial with enzyme-like catalytic activity. Tumor microenvironment has its own unique biochemical characteristics, and this review summarizes that stimulating responsive nanozyme in tumor microenvironment can promote ROS production to enhance chemodynamic therapy in situ, by regulating acidity, increasing H2O2 concentration, changing glucose metabolism, eliminating antioxidants. Based on this, the research progress of nanozyme catalytic therapy synergistic photodynamic therapy, photothermal therapy, sonodynamic therapy, radiotherapy and immunotherapy were further reviewed.

Key words: nanozyme, cascade catalytic reaction, stimulus response mechanism, catalytic treatment, tumor treatment, immunotherapy

CLC Number: 

  • TB383.1
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