Journal of Guangxi Normal University(Natural Science Edition) ›› 2013, Vol. 31 ›› Issue (2): 81-86.

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Crystal Structure and Antitumor Activity of a New Schiff Base Palladium Complex

CHEN Si-yuan1,2, YANG Yang1,2, PENG Yan1,2, LIU Yan-cheng1,2   

  1. 1.College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Guilin Guangxi 541004,China
  • Received:2012-09-15 Online:2013-06-20 Published:2018-11-26

Abstract: A new Schiff base 3,4-methylenedioxy-phenethylamine-pyridine-2-formaldehyde (L),was synthesized as ligand.The reaction of L with PdCl2 afforded the first palladium(Ⅱ) complex of L (complex 1).Complex 1 was characterized by IR,elemental analysis,ESI-MS,and structurally determined by X-ray single crystal diffraction analysis.In vitro cytotoxicity test against six human tumor cell lines by MTT method showed that complex 1exhibited significant cytotoxicity against the MDA-MB-231 tumor cell,with IC50 value of (6.98±1.43) μmol/L,while low cytotoxicity to the other fivetumor cell lines (including A549,HeLa,NCI-H460,MGC80-3 and BEL7404),which indicatedthat complex 1 showed some cytotoxic selectivity on these tested tumor cell lines,suggesting its potential for the antitumoral applications.

Key words: Schiff base, palladium(Ⅱ) complex, crystal structure, antitumor activity

CLC Number: 

  • O641.4
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