Journal of Guangxi Normal University(Natural Science Edition) ›› 2016, Vol. 34 ›› Issue (2): 105-110.doi: 10.16088/j.issn.1001-6600.2016.02.015

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Synthesis and Crystal Structure of 2-[1,3-bis(2-hydroxy benzyl)-5-pyridyl-4-imidazolidinyl] phenol

WANG Yana, LIN Jiahuang, NI Qingling, ZHANG Fang, YU Ronghua, WANG Xiujian   

  1. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2016-01-20 Online:2016-06-25 Published:2018-09-14

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Abstract: Sailcylaldehyde reacts respectively with 2-aminomethylpyridine and 4-aminomethylpyridine to afford two bis-schiff bases, whose reduction products,2-[1,2-bis{[(E)-(2-hydroxyphenyl)methylidene]amino}-2-pyridinylethyl]phenol (1a,1b), further react with formaldehyde to produce two novel imidazolines derivates,2-[1,3-bis(2-hydroxy benzyl)-5- (2-pyridyl)-4-imidazolidinyl] phenol(2a) and 2-[1,3-bis(2-hydroxy benzyl)-5-(4-pyridyl)-4-imidazolidinyl] phenol(2b). Their structures were characterized by 1H NMR, 13C NMR, IR and X-ray single-crystal diffraction(2a). 2a belongs to monoclinic system, space group P2(1)/n with a=1.346 0(4) nm, b=1.477 1(4) nm, c=1.202 7(5) nm, β=100.490 0(1)°, V=2.351 1(14) nm3, Dc=1.281 mg/cm-3, Z=4, F(000)=960.439 0, μ=0.08 mm-1.

Key words: sailcylaldehyde, aminomethylpyridine, imidazoline, synthesis, crystal structure

CLC Number: 

  • O626.2
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