Journal of Guangxi Normal University(Natural Science Edition) ›› 2016, Vol. 34 ›› Issue (2): 111-115.doi: 10.16088/j.issn.1001-6600.2016.02.016

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Synthesis and Antitumor, Antibacterial ActivityEvaluation of Ferrocene-quinolone Hybrids

HUANG Wanyun1,2,3, YIN Penglong1, LI Hong1, PENG Xiangyan1, SU Guifa2,3   

  1. 1. Department of Pharmacology, Guilin Medical University, Guilin Guangxi 541004, China;
    2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guilin Guangxi 541004, China;
    3. College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2015-11-26 Online:2016-06-25 Published:2018-09-14

Abstract: Five novel ferrocene-quinolone hybrids were firstly synthesized via esterification, hydrazinolysis and then condensation with ferrocenecarbaldehyde. Their structures were characterized by IR, NMR and HRMS. The results indicated that the target compounds really showed strong inhibitory activity against several tumor cell lines, which would probably provide a new strategy for the design of novel antitumor drugs based on the quinolone skeleton.

Key words: quinolone, ferrocene, hybrids, antitumor activity, antibacterial activity

CLC Number: 

  • O626.25
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