广西师范大学学报（自然科学版） ›› 2026, Vol. 44 ›› Issue (2): 1-16.doi: 10.16088/j.issn.1001-6600.2025051801

• 综述 •    下一篇

萝藦科药用植物中新C21甾体的研究进展(Ⅱ)

徐秀虹, 张进燕, 卢羽玲, 梁小平, 廖广凤, 卢汝梅*   

  1. 广西中医药大学 药学院,广西 南宁 530200
  • 收稿日期:2025-05-18 修回日期:2025-06-16 发布日期:2026-02-03
  • 通讯作者: 卢汝梅(1969—),女,广西陆川人,广西中医药大学教授,博士。E-mail: lrm1969@163.com
  • 基金资助:
    国家自然科学基金(82360823);广西自然科学基金青年基金(2025GXNSFBA069359);广西高校中青年教师科研基础能力提升项目(2025KY0365);广西特色中药现代产业学院大学生创新创业训练计划立项项目(C202404)

Research Progress of New C21 Steroids in Medicinal Plants of Asclepiadaceae(Ⅱ)

XU Xiuhong, ZHANG Jinyan, LU Yuling, LIANG Xiaoping, LIAO Guangfeng, LU Rumei*   

  1. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China
  • Received:2025-05-18 Revised:2025-06-16 Published:2026-02-03

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摘要： C21甾类化合物是一类母核中含有21个碳原子的甾体衍生物,具有抗肿瘤、增强免疫、抗氧化、抗癫痫、降血脂等多方面的药理活性,具有十分重要的药用价值。萝藦科Asclepiadaceae植物是天然C21甾体的主要来源之一。统计相关文献发现,近20年从萝藦科中分离出的新C21甾体化合物913个,根据骨架上取代基的数量、性质及其不饱和程度,将其结构分为9种类型(Ⅰ～Ⅸ型),其中Ⅰ型为孕甾烷,Ⅱ～Ⅸ型为变形孕甾烷。孕甾烷和变形孕甾烷在空间结构、生物活性和代谢途径上具有差异,使变形孕甾烷成为药物研发和化学生物学研究重点。本文主要对Ⅱ～Ⅸ型变形孕甾烷的分布及其理化性质、波谱特征进行介绍。

关键词: 萝藦科, 孕甾烷, 结构特征, 理化性质

Abstract: C21 steroids are a class of steroid derivatives containing 21 carbon atoms in the parent nucleus. They have many pharmacological activities such as anti-tumor, immune enhancement, anti-oxidation, anti-epilepsy, and hypolipidemic, and demonstrating significant medicinal value. Asclepiadaceae plants are one of the main sources of natural C21 steroids. According to the relevant literature, nearly 913 new C21 steroidal compounds were isolated from Asclepiadaceae in the past 20 years. According to the number, properties and degree of unsaturation of the substituents on the skeleton, their structures were divided into 9 types (I-IX), of which type I was pregnane and type II-IX was deformed pregnane. Pregnane and deformed pregnane differ in spatial structure, biological activity and metabolic pathway, which makes deformed pregnane become the focus of drug development and chemical biology research. In this paper, the distribution, physicochemical properties and spectral characteristics of type II-IX modified pregnane were introduced.

Key words: Asclepiadaceae, pregnane, structural characteristics, physicochemical property

中图分类号:  R284;O629

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