广西师范大学学报（自然科学版） ›› 2021, Vol. 39 ›› Issue (5): 1-29.doi: 10.16088/j.issn.1001-6600.2020110903

• 综述 •    下一篇

萝藦科药用植物中新C21甾体的研究进展(Ⅰ)

詹鑫, 陈李璟, 廖广凤, 李兵, 卢汝梅*   

  1. 广西中医药大学 药学院,广西 南宁 530200
  • 收稿日期:2020-11-09 修回日期:2021-01-16 出版日期:2021-09-25 发布日期:2021-10-19
  • 通讯作者: 卢汝梅(1969—),女,广西陆川人,广西中医药大学教授,博士。E-mail:lrm1969@163.com
  • 基金资助:
    国家自然科学基金(81860750);广西壮瑶药重点实验室项目(桂科基字[2014]32号)

Research Progress of New C21-Steroids in Medicinal Plant of Asclepiadaceae (Ⅰ)

ZHAN Xin, CHEN Lijing, LIAO Guangfeng, LI Bing, LU Rumei*   

  1. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China
  • Received:2020-11-09 Revised:2021-01-16 Online:2021-09-25 Published:2021-10-19

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摘要： C21甾体是一类母核含有21个碳原子的甾体衍生物,是孕甾烷或其异构体的衍生物,有抗肿瘤、抗炎、镇痛、抗生育、抗抑郁、免疫调节等多方面的药理活性,具有十分重要的药用价值。萝藦科植物是天然C21甾体的主要来源之一。根据相关文献统计,近20年来从萝藦科药用植物中分离鉴定的新C21甾体化合物共624种,包含9种不同的骨架类型。我们分3部分对21世纪以来萝藦科植物中C21甾体的分布、结构特征及药理活性进行综述,以期为C21甾体的深入研究和开发利用提供参考,为探索萝藦科植物的药用价值和药效物质基础提供科学依据。本文综述萝藦科植物中孕甾烷型C21甾体的分布、结构特征、理化性质及波谱特征。

关键词: 萝藦科, C21甾体, 分布, 结构特征, 波谱特征

Abstract: C21-steroids is a steroid derivative with 21 carbon atoms in the parent nucleus, and it is a derivative of pregnanes or its isomer. It has many pharmacological activities such as anti-tumor, anti-inflammation and analgesia, anti-fertility, anti-depression and immune regulation, etc. The plant of the family Asclepiadaceae is one of the main sources of natural C21-steroids. According to the statistics of relevant literature, 624 new C21-steroidal compounds were isolated and identified from the medicinal plant of Asclepiadaceae in the past 2 decades, including 9 different skeleton types. In this paper, the distribution, structural characteristics and pharmacological activities of C21-steroids in plants of Asclepiadaceae since 2000s were summarized in three parts, in order to provide references for the further research, development and utilization of C21-steroids, and to provide scientific basis for exploring the medicinal value and therapeutic basis of the plants of Asclepiadaceae. At the beginning of this paper, the distribution, structural characteristics, physicochemical properties and spectra of the prene-type C21-steroids in plants of Asclepiadaceae were reviewed.

Key words: Asclepiadaceae, C21-steroids, distribution, structural characteristics, spectral characteristics

中图分类号: 

  • O629.2
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