赤苍藤化学成分及其抗炎活性研究

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赤苍藤化学成分及其抗炎活性研究

Chemical Constituents and Anti-inflammatory Activities of Erythropalum scandens Bl.

赤苍藤化学成分及其抗炎活性研究

Chemical Constituents and Anti-inflammatory Activities of Erythropalum scandens Bl.

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doi:10.16088/j.issn.1001-6600.2024082002

广西师范大学学报（自然科学版） ›› 2025, Vol. 43 ›› Issue (2): 258-264.doi: 10.16088/j.issn.1001-6600.2024082002

• 药用资源研究 • 上一篇

高德凤^1,2,3,4,5#, 石志棉^1,2,3,4,5#, 豆博强^2,3,4,5, 韦海叶^2,3,4,5, 李玉妍^2,3,4,5, 黄艳^6*, 苏骏成^2,3,4,5*

1.广西壮族自治区南溪山医院(广西壮族自治区第二人民医院) 药学部, 广西桂林541002;
2.省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学), 广西桂林 541004;
3.药用资源化学与药物分子工程教育部重点实验室(广西师范大学), 广西桂林 541004;
4.广西民族药省部共建协同创新中心(广西师范大学), 广西桂林 541004;
5.广西师范大学化学与药学学院, 广西桂林 541004;
6.广西中药质量标准研究重点实验室(广西壮族自治区中医药研究院), 广西南宁 530022

收稿日期:2024-08-20 修回日期:2024-09-18 出版日期:2025-03-05 发布日期:2025-04-02
通讯作者: 黄艳(1987—), 女, 广西合浦人, 广西中医药研究院副研究员, 博士。Email: hy2002-2006@163.com;苏骏成(1990—), 男(壮族), 广西桂林人, 广西师范大学副教授, 博士。E-mail: sujuncheng@gxnu.edu.cn
作者简介:#为共同第一作者
基金资助:
广西自然科学基金(2024GXNSFBA010210); 广西中药质量标准研究重点实验室(广西壮族自治区中医药研究院)开放基金(桂中重开202403)

GAO Defeng^1,2,3,4,5#, SHI Zhimian^1,2,3,4,5#, DOU Boqiang^2,3,4,5, WEI Haiye^2,3,4,5, LI Yuyan^2,3,4,5, HUANG Yan^6*, SU Juncheng^2,3,4,5*

1. Department of Pharmacy, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin Guangxi 541002, China;
2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
3. Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China, Guilin Guangxi 541004, China;
4. Collaborative Innovation Center for Guangxi Ethnic Medicine (Guangxi Normal University), Guilin Guangxi 541004, China;
5. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China;
6. Guangxi Key Laboratory of TCM Quality Standard Research (Guangxi Academy of Traditional Chinese Medicine), Nanning Guangxi 530022, China

Received:2024-08-20 Revised:2024-09-18 Online:2025-03-05 Published:2025-04-02

摘要： 赤苍藤作为一种具有较高开发潜力的药食同源植物,是目前广西大力推荐种植的经济作物之一,但其物质基础研究匮乏,直接导致其在产品开发、市场推广等多个环节上严重受限。为了揭示赤苍藤的药效物质基础,本文从赤苍藤中分离并鉴定了11个化合物,均为首次从赤苍藤属植物中分离得到。结构上,这些化合物分别属于倍半萜、甾体、苯丙素、聚酮等多种结构类型。药理活性研究结果表明,这些化合物均具有一定的抗炎活性,其中acetanilide的抗炎活性优于临床抗炎药物吲哚美辛。研究结果为深入探究赤苍藤的药用价值和开发新药物提供重要参考。

关键词: 赤苍藤, 赤苍藤属, 化学成分, 抗炎活性

Abstract: Erythropalum scandens Blume is a leafy vegetable and emerging medicinal plant widely distributed in Guangxi, China. However, the product development of the title plant is limited due to the insufficient investigations on its secondary metabolites. To uncover the bioactive components of E. scandens, herein, the results of a systematic phytochemical investigation on E. scandens were reported, which were the isolation and structural characterization of 11 compounds belonging to different structural types. All the compounds were reported from the genus Erythropalum for the first time. Moreover, all the isolated compounds showed moderate to good anti-inflammatory activity against LPS-stimulated RAW264.7 cells, with acetanilide being the most potent example, which possessed better potency compared with the clinical anti-inflammatory drug indomethacin.

Key words: Erythropalum scandens Bl., Erythropalum Bl., chemical composition, anti-inflammatory activity

中图分类号: R284.1

高德凤, 石志棉, 豆博强, 韦海叶, 李玉妍, 黄艳, 苏骏成. 赤苍藤化学成分及其抗炎活性研究[J]. 广西师范大学学报（自然科学版）, 2025, 43(2): 258-264.

GAO Defeng, SHI Zhimian, DOU Boqiang, WEI Haiye, LI Yuyan, HUANG Yan, SU Juncheng. Chemical Constituents and Anti-inflammatory Activities of Erythropalum scandens Bl.[J]. Journal of Guangxi Normal University(Natural Science Edition), 2025, 43(2): 258-264.

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