地蚕的化学成分研究

doi:10.16088/j.issn.1001-6600.2022031001

广西师范大学学报（自然科学版） ›› 2023, Vol. 41 ›› Issue (2): 124-130.doi: 10.16088/j.issn.1001-6600.2022031001

地蚕的化学成分研究

闫梦麒¹, 韦易伸¹, 黄婉仪¹, 王力生¹, 覃江克², 周先丽³, 梁成钦^1*

1.桂林医学院药学院,广西桂林 541199;
2.省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学),广西桂林 541004;
3.桂林医学院生物技术学院,广西桂林 541199

收稿日期:2022-03-10 修回日期:2022-04-04 出版日期:2023-03-25 发布日期:2023-04-25
通讯作者: 梁成钦(1977—),男,广西平南人,桂林医学院副教授,博士。E-mail:cqliang@glmc.edu.cn
基金资助:
国家自然科学基金(81860621);广西自然科学基金(2018GXNSFBA281032)

Chemical Constituents of Stachys geobombycis C. Y. Wu

YAN Mengqi¹, WEI Yishen¹, HUANG Wanyi¹, WANG Lisheng¹, QIN Jiangke², ZHOU Xianli³, LIANG Chengqin^1*

1. College of Pharmacy, Guilin Medical University, Guilin Guangxi 541199, China;
2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
3. College of Biotechnology, Guilin Medical University, Guilin Guangxi 541199, China

Received:2022-03-10 Revised:2022-04-04 Online:2023-03-25 Published:2023-04-25

摘要/Abstract

摘要： 利用硅胶柱色谱、Sephdex LH-20柱色谱以及半制备HPLC等方法,从地蚕中分离得到14个化合物,通过现代波谱技术鉴定其结构,分别为:酪醇(1)、烟酰胺(2)、2,2-bis[4-(2,3-dihydroxypropoxy)phenyl]propane(3)、香草酸(4)、丁香酸(5)、5-(α-D-吡喃半乳糖基-(1→6)-α-D-吡喃半乳糖基氧甲基)-2-呋喃甲醛(6)、8-O-acetyl harpagide(7)、地黄苷(8)、邻苯二甲酸二丁酯(9)、tatarine C-4′-O-β-D-glucopyranoside(10)、bis(2-ethylhexyl) benzene-1,2-dicarboxylate(11)、5-(α-D-半乳吡喃氧基甲基)-2-呋喃甲醛(12)、5-羟甲基呋喃甲醛(13)和焦谷氨酸正丁酯(14)。其中化合物1~4和6~14均为首次从该植物中分离得到。

关键词: 地蚕, 分离纯化, 结构鉴定, 化学成分

Abstract: The compounds were isolated and purified from Stachys geobombycis by column chromatography with silica gel, Sephadex LH-20 and semi-preparative HPLC, and their structures were identified by modern spectral data. Fourteen compounds were isolated and identified as tyrosol (1), nicotinamide (2), 2, 2-bis[4-(2, 3-dihydroxypropoxy) phenyl] propane (3), vanillic acid (4), syringate (5), 5-(α-D-galactopyranosyl-(1-6)-α-D-galactopyranosyloxymeth-yl)-2-furancarboxaldehyde (6), 8-O-acetyl harpagide (7), martynoside(8), dibutyl phthalate (9), tatarine C-4′-O-β-D-glucopyranoside (10), bis (2-ethylhexyl) benzene-1,2-dicarboxylate(11), (5-(α-D-galactopyranosyloxymethyl)-2-furancarboxaldehyde) (12), 5-hydroxymethyl-furaldehyde (13) and n-butyl pyroglutamate (14). Among them, compounds 1-4 and 6-14 were isolated from the S. geobombycis for the first time.

Key words: Stachys geobombycis C.Y.Wu, separation and purification, structure identification, chemical composition

中图分类号:

R284.1

闫梦麒, 韦易伸, 黄婉仪, 王力生, 覃江克, 周先丽, 梁成钦. 地蚕的化学成分研究[J]. 广西师范大学学报（自然科学版）, 2023, 41(2): 124-130.

YAN Mengqi, WEI Yishen, HUANG Wanyi, WANG Lisheng, QIN Jiangke, ZHOU Xianli, LIANG Chengqin. Chemical Constituents of Stachys geobombycis C. Y. Wu[J]. Journal of Guangxi Normal University(Natural Science Edition), 2023, 41(2): 124-130.

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地蚕的化学成分研究

Chemical Constituents of Stachys geobombycis C. Y. Wu

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