广西师范大学学报（自然科学版） ›› 2023, Vol. 41 ›› Issue (2): 27-35.doi: 10.16088/j.issn.1001-6600.2022031701

• 综述 • 上一篇    下一篇

白介素-31参与瘙痒的研究进展

李康良1, 邱彩雄1, 何爽1, 黄春华2, 伍冠一1*   

  1. 1.广西中医药大学 基础医学院,广西 南宁 530299;
    2.广西中医药大学 药学院,广西 南宁 530299
  • 收稿日期:2022-03-17 修回日期:2022-06-03 出版日期:2023-03-25 发布日期:2023-04-25
  • 通讯作者: 伍冠一(1980—),男,广西北海人,广西中医药大学教授,博士。E-mail:w5gy1@126.com
  • 基金资助:
    国家自然科学基金(81860740, 82060768);广西自然科学基金(2020JJA140311)

Research Progress of IL-31 in Itch

LI Kangliang1, QIU Caixiong1, HE Shuang1, HUANG Chunhua2, WU Guanyi1*   

  1. 1. College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning Guangxi 530299, China;
    2. College of Pharmacology, Guangxi University of Chinese Medicine, Nanning Guangxi 530299, China
  • Received:2022-03-17 Revised:2022-06-03 Online:2023-03-25 Published:2023-04-25

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摘要： 瘙痒是很多皮肤疾病的常见临床症状,包括特应性皮炎、结节性痒疹、银屑病、慢性荨麻疹等。最近的研究表明,白介素-31在皮肤疾病的瘙痒中扮演重要角色。白介素-31可由CD4+辅助T细胞、肥大细胞、角化细胞、巨噬细胞、树突状细胞等合成与释放,通过激活白介素-31异二聚体受体(IL-31受体A 和抑瘤素受体M)产生痒觉相关信号。尽管研究发现白介素-31可通过直接或间接的作用向神经中枢传递痒觉信号,但是它的致痒机制尚不完全清楚。本文就白介素-31的基因、受体、来源以及在瘙痒相关疾病中的作用展开综述。

关键词: 白介素-31, 瘙痒, 皮肤疾病, 白介素-31受体, 角化细胞, 肥大细胞

Abstract: Itch is a normal symptom in many skin diseases such as atopic dermatitis, prurigo nodularis, psoriasis, and chronic urticaria. More and more data show that interleukin-31 (IL-31) plays an important role in itch. IL-31 is composed and released from CD4+ help T cell, mast cells, keratinocytes, macrophages, and dendritic cells. By activating interleukin-31 heterodimer receptors (IL-31 receptor A and tumor suppressor M receptor), itch related signals are generated. Although it has been found that IL-31 can transmit itch signals to the central nerve system directly or indirectly, mechanism of itch is not fully understood. This review summarizes the current knowledge on IL-31's gene, source, receptor, and the effect of IL-31 in pruritic diseases.

Key words: IL-31, itch, skin diseases, IL-31 receptor, keratinocytes, mast cells

中图分类号: 

  • R751
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