广西师范大学学报（自然科学版） ›› 2023, Vol. 41 ›› Issue (1): 24-37.doi: 10.16088/j.issn.1001-6600.2022011605

• 综述 • 上一篇    下一篇

近5年两面针的化学成分及药理活性研究进展

陈瑶1,2,3,4, 李梅珊1,2,3,4, 覃锋1,2,3,4, 王恒山1,2,3,4*   

  1. 1.广西师范大学化学与药学学院, 广西桂林 541004;
    2.省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学),广西 桂林 541004;
    3.药用资源化学与药物分子工程教育部重点实验室(广西师范大学), 广西桂林 541004;
    4.广西民族药省部共建协同创新中心(广西师范大学), 广西 桂林 541004
  • 收稿日期:2022-01-16 修回日期:2022-03-25 出版日期:2023-01-25 发布日期:2023-03-07
  • 通讯作者: 王恒山(1965—),男,浙江温州人,广西师范大学教授,博导。E-mail:whengshan@163.com
  • 基金资助:
    国家自然科学基金(21977021, 81760626, 22111530012); 广西自然科学基金(AB17292075)

Research Progress on Chemical Components and Pharmacological Effects of Zanthoxylum nitidum (Roxb.) DC. in Recent Five Years

CHEN Yao1,2,3,4, LI Meishan1,2,3,4, QIN Feng1,2,3,4, WANG Hengshan1,2,3,4*   

  1. 1. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China;
    2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
    3. Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education, Guilin Guangxi 541004, China;
    4. Collaborative Innovation Center for Guangxi Ethnic Medicine (Guangxi Normal University),Guilin Guangxi 541004, China
  • Received:2022-01-16 Revised:2022-03-25 Online:2023-01-25 Published:2023-03-07

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摘要： 两面针Zanthoxylum nitidum (Roxb.) DC.属于芸香科花椒属植物,在我国主要分布于广西、福建、广东、云南等地,作为传统植物药,在我国拥有悠久的药用历史。其根、茎、叶、果皮均可药用,具有活血化瘀、行气止痛、祛风通络、解毒消肿等功效,是广西特色民族药之一,为瑶族的经典老班药“入山虎”和壮药“两北针”。目前,两面针植物中已发现的化学成分主要有生物碱、香豆素、木脂素、黄酮类及其他类型的化合物,具有抗炎、镇痛、止血、抗肿瘤、抗菌等药理作用。通过文献检索和本课题组研究积累,本文对近5年来国内外两面针化学成分和药理活性进行综述,旨在为进一步研究和开发两面针的药用价值提供参考。

关键词: 两面针, 生物碱类, 香豆素类, 抗炎, 抗菌, 抗癌

Abstract: Zanthoxylum nitidum (Roxb.) DC., a kind of Zanthoxylum plant of Rutaceae family, is mainly distributed in Guangxi, Fujian, Guangdong and Yunnan provinces in China. The root, stem, leaf and peel ofZ. nitidum can be used for medicine, which has the effects of promote blood circulation to remove blood stasis, promote qi circulation to relieve pain, disperse wind to dredge collaterals and remove toxicity to achieve detumescence. It is one of the national medicines with Guangxi characteristics, and is the classic Laoban medicine of Yao people “Ru Shan Hu” and Zhuang medicine “Liang Bei Zhen”. At present, the chemical components isolated from Z. nitidum, including alkaloids, coumarins, lignans, flavonoids and other compounds, which possess anti-inflammatory, analgesic, hemostatic, antitumor, antibacterial and other pharmacological effects. The chemical constituents and pharmacological activities of Z. nitidum at home and abroad in recent five years are reviewed based on literatures search in this paper, which will provide references for further research and development of the medicinal values of this plant.

Key words: Zanthoxylum nitidum (Roxb.) DC., alkaloid, coumarin, anti-inflammatory, antibacterial, anticancer

中图分类号: 

  • R284
[1] 艾双艳. 全蝎和两面针化学成分研究[D]. 天津:天津理工大学,2017.
[2]LIN Z H. Innovation leader of Liang-Mian-Zhen[J]. Oral Care Ind,2019,29(5):49-52.
[3]CHAKTHONG S,AMPAPROM R,INPARN S,et al. New alkylamide from the stems of Zanthoxylum nitidum[J]. Natural Product Research,2019,33(2):153-161. DOI:10.1080/14786419.2018.1440218.
[4]陈仕鹏. 两面针根水提物化学成分及氯化两面针碱抗肝癌的分子机制研究[D]. 南宁:广西医科大学,2019.
[5]HUANG A H,CHI Y G,LIU J W,et al. Profling and pharmacokinetic studies of alkaloids in rats after oral administration of Zanthoxylum nitidum decoction by UPLC-Q-TOF-MS/MS and HPLC-MS/MS[J]. Molecules,2019,24(3):585. DOI:10.3390/molecules24030585.
[6]纪梦颖. 两面针化学成分的分离与鉴定[D]. 广州:广州中医药大学,2018.
[7]LIU M Z,LIU Q,CHEN M. Large-scale separation of acetylcholinesterase inhibitors from Zanthoxylum nitidum by pH-zone-rening counter-current chromatography target-guided by ultra ltration high-performance liquid chromatography with ultraviolet and mass spectrometry screening[J]. Journal of Separation Science,2019,42(6):1194-1201. DOI:10.1002/jssc.201801238.
[8]LU Q,MA R F, YANG Y, et al. Zanthoxylum nitidum(Roxb.) DC:traditional uses, phytochemistry, pharmacological activities and toxicology[J]. Journal of Ethnopharmacology,2020,260:112946. DOI:10.1016/j.jep.2020.112946.
[9]LU Q,ZHANG Z S,ZHAN R T,et al. Proteomic analysis of Zanthoxylum nitidum seeds dormancy release:inuence of stratication and gibberellin[J]. Industrial Crops and Products,2018,122:7-15. DOI:10.1016/j.indcrop.2018.05.044.
[10]赵丽娜,王佳,汪哲,等. 中药两面针的化学成分及细胞毒活性成分研究[J]. 中国中药杂志,2018,43(23):4659-4664. DOI:10.19540/j.cnki.cjcmm.20180926.001.
[11]邬国松,郑丽婷,马庆,等. 基于网络药理学的两面针干预炎症靶点预测及作用机制研究[J]. 中草药,2019,50(3): 659-668.
[12]HONG VAN N T, TUYEN T T, QUAN P M,et al. Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum[J]. Phytochemistry Letters,2019,32:47-51. DOI:10.1016/j.phytol.2019.04.022.
[13]倪媛媛. 两面针质量控制及基于斑马鱼模型评价两面针和苍耳子初步毒性研究[D]. 北京:北京中医药大学,2018.
[14]彭招华,吴孟华,谢志坚,等. 两面针野生资源现状调查[J]. 今日药学,2018,28(7):500-504. DOI:10.12048/j.issn.1674-229X.2018.07.020.
[15]苏桂云,黄硕. 活血行气祛风解毒的两面针[J]. 首都食品与医药,2016,23(9):61.
[16]秦云蕊,蒋珍藕,赖茂祥,等. 两面针基原植物考证及其活性成分含量分析[J]. 广西植物,2019,39(4):531-539. DOI:10.11931/guihaia.gxzw201804012.
[17]覃迅云. 中国瑶药学[M]. 北京:民族出版社,2002.
[18]沈晓华,穆淑珍,王青遥,等. 滇产两面针化学成分的分离与鉴定[J]. 沈阳药科大学学报,2016,33(4):275-279,292.
[19]弓艳君. 山豆根两面针为主治疗100例口腔溃疡的临床观察[J]. 内蒙古中医药,2007,26(7):9. DOI:10.3969/j.issn.1006-0979.2007.07.005.
[20]黄琪,雷鹏,欧阳冬生. 芸香科花椒属植物两面针抗肿瘤作用研究进展[J]. 肿瘤药学,2011,1(6):482-485. DOI:10.3969/j.issn.2095-1264.2011.06.002.
[21]庞辉,汤桂芳,何惠,等. 两面针提取物对小鼠实验性肝损伤的保护作用[J]. 广西医学,2006,28(10):1606-1608. DOI:10.3969/j.issn.0253-4304.2006.10.062.
[22]庞辉,何惠,简丽娟,等. 两面针总碱抗胃溃疡作用研究[J]. 中药药理与临床,2007,23(1):38-39. DOI:10.3969/j.issn.1001-859X.2007.01.020.
[23]刘绍华,覃青云,唐献兰,等. 两面针的药学研究与开发利用[J]. 广西科学院学报,2005,21(2):130-132. DOI:10.3969/j.issn.1002-7378.2005.02.018.
[24]陈蔚文,徐鸿华. 岭南道地药材研究[M]. 广州:广东科技出版社,2007:376-382.
[25]秦泽慧. 基于化学成分及药理活性的两面针根茎部位药用价值评价[D]. 广州:广州中医药大学,2013.
[26]黄兆祥. 两面针治疗腰痛[J]. 中国民间疗法,1999,7(7):44. DOI:10.3969/j.issn.1007-5798.1999.07.079.
[27]辛宁,甄汉深. 两面针的研究[J]. 时珍国药研究,1996,7(2):118-119.
[28]刘光瑞,刘少林. 中国民间中草药[M]. 成都:四川科学技术出版社,2008:158.
[29]NGUYEN T H V,TRAN T T,CAM T I,et al. Alkaloids from Zanthoxylum nitidum and their cytotoxic activity[J]. Natural Product Communications,2019,14(5):1-5. DOI:10.1177/1934578X19844133.
[30]ZHAO L N,GUO X X,LIU S,et al.(±)-Zanthonitidine A,a pair of enantiomeric furoquinoline alkaloids from Zanthoxylum nitidum with antibacterial activity[J]. Natural Products and Bioprospecting,2018,8(5):361-367. DOI:10.1007/s13659-018-0169-7.
[31]LIAO N,LI M S,QIN F,et al. A new phenolic acid from Zanthoxylum nitidum var. tomentosum(Rutaceae) and its chemotaxonomic significance[J]. Biochemical Systematics and Ecology,2021,99:104351. DOI:10.1016/j.bse.2021.104351.
[32]ZUO G Y,WANG C J,HAN J,et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus(MRSA)[J]. Phytomedicine,2016,23(14):1814-1820. DOI:10.1016/j.phymed.2016.11.001.
[33]ZHOU L,CHEN W C,HE W Q,et al. A new coumarin from Zanthoxylum nitidum[J]. Chemistry of Natural Compounds,2019,55(6):1010-1013. DOI:10.1007/s10600-019-02881-7.
[34]QIN F,WANG F F,WANG C G,et al. The neurotrophic and antineuroinflammatory effects of phenylpropanoids from Zanthoxylum nitidum var. tomentosum(Rutaceae)[J]. Fitoterapia,2021,153:104990. DOI:10.1016/j.fitote.2021.104990.
[35]QIN F,WANG C Y,KIM D,et al. Nitidumpeptins A and B,cyclohexapeptides isolated from Zanthoxylum nitidum var. tomentosum:structural elucidation,total synthesis,and antiproliferative activity in cancer cells[J]. The Journal of Organic Chemistry,2021,86(2):1462-1470. DOI:10.1021/acs.joc.0c02057.
[36]QIN F,WANG C Y,HU R C,et al. Anti-inflammatory activity of isobutylamides from Zanthoxylum nitidum var. tomentosum[J]. Fitoterapia,2020,142:104486. DOI:10.1016/j.fitote.2020.104486.
[37]CUI X G,ZHAO Q J,CHEN Q L,et al. Two new benzophenanthridine alkaloids from Zanthoxylum nitidum[J]. Helvetica Chimica Acta,2008,91(1):155-158. DOI:10.1002/hlca.200890006.
[38]DEYUN K,GRAY A I,HARTLEY T G,et al. Alkaloids from an Australian accession of Zanthoxylum nitidum (Rutaceae)[J]. Biochemical Systematics & Ecology,1996,24(1):87-88. DOI:10.1016/0305-1978(95)00096-8.
[39]FANG S D,WANG L K,HECHT S M. Inhibitors of DNA topoisomerase I isolated from the roots of Zanthoxylum nitidum[J]. Journal of Organic Chemistry,1993,58(19):5025-5027. DOI:10.1021/jo00071a001.
[40]耿頔,李定祥,施瑶,等. 两面针中一个新的苯并菲啶类生物碱[J]. 中国天然药物,2009,7(4):274-277. DOI:10.3724/SP.J.1009.2009.00274.
[41]李定祥,闵知大. 两面针中生物碱的分离[J]. 中国天然药物,2004,2(5):285-288.
[42]文屏,李加福,高咏莉,等. 两面针中白屈菜红碱等成分的抗炎活性研究[J]. 今日药学,2018,28(4):217-220,232. DOI:10.12048/j.issn.1674-229X.2018.04.001.
[43]YANG N,YUE R C,MA J Z,et al. Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production[J]. Pharmacological Research,2019,148:104368. DOI:10.1016/j.phrs.2019.104368.
[44]QIN F F,ZHANG H,LIU A L,et al. Analgesic effect of Zanthoxylum nitidum extract in inammatory pain models through targeting of ERK and NF-κB signaling[J]. Frontiers in Pharmacology,2019,10:359. DOI:10.3389/fphar.2019.00359.
[45]CUI Y,WU L H,CAO R X,et al. Antitumor functions and mechanisms of nitidine chloride in human cancers[J]. Journal of Cancer,2020,11(5):1250-1256. DOI:10.7150/jca.37890.
[46]SUN M J,ZHANG N,WANG X L,et al. Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells[J]. Cell and Bioscience,2016,6:44. DOI:10.1186/s13578-016-0104-8.
[47]LIU L M,XIONG D D?IN P,et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride[J]. International Journal of Oncology,2018,53(5):1897-1912. DOI:10.3892/ijo.2018.4531.
[48]XIONG D D,FENG Z B,LAI Z F,et al. High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma[J]. Cell Death & Disease,2019,10(9):658. DOI:10.1038/s41419-019-1890-9.
[49]SUN X X,LIN L,CHEN Y,et al. Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway[J]. Molecular Medicine Reports,2016,13(4):3161-3168. DOI:10.3892/mmr.2016.4929.
[50]DING F,LIU T F,YU N N,et al. Nitidine chloride inhibits proliferation,induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells[J]. Molecular Medicine Reports,2016,14(3):2853-2859. DOI:10.3892/mmr.2016.5577.
[51]MOU H P,GUO P,LI X M,et al. Nitidine chloride inhibited the expression of S phase kinase-associated protein 2 in ovarian cancer cells[J]. Cell Cycle,2017,16(14):1366-1375. DOI:10.1080/15384101.2017.1327490.
[52]CHEN S P,YANG L,FENG J. Nitidine chloride inhibits proliferation and induces apoptosis in ovarian cancer cells by activating the fas signalling pathway[J]. Journal of Pharmacy and Pharmacology,2018,70(6):778-786. DOI:10.1111/jphp.12901.
[53]ZHOU J L,YANG X L,WANG X M,et al. Side population were reduced by nitidine chloride through suppressing STAT3/c-myc signaling via miR-17-5p in gastric cancer[J]. International Journal of Clinical and Experimental Medicine,2016,9(12):23144-23153.
[54]KWON H J,KIM L H,AHN C H,et al. A new insight into the apoptotic effect of nitidine chloride targeting Checkpoint kinase 2 in human cervical cancer in vitro[J]. Journal of Clinical Biochemistry and Nutrition,2019,65(3):193-202. DOI:10.3164/jcbn.19-28.
[55]宋瑾,周利琴,林钻煌,等. 中草药提取物体外止血效果评价模型[J]. 广西科学,2017,24(4):407-412.
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