广西师范大学学报（自然科学版） ›› 2019, Vol. 37 ›› Issue (1): 181-186.doi: 10.16088/j.issn.1001-6600.2019.01.021

• 第二十四届全国信息检索学术会议专栏 • 上一篇    下一篇

木荷树皮乙醇提取物抗炎镇痛作用研究

邓志勇, 骆海玉, 陈超英, 邓业成*, 孙文斌, 梁芳铭   

  1. 广西师范大学生命科学学院,广西桂林541006
  • 收稿日期:2017-09-25 出版日期:2019-01-20 发布日期:2019-01-08
  • 通讯作者: 邓业成(1965—),男,广西全州人,广西师范大学教授,博士。E-mail:dyecheng@163.com
  • 基金资助:
    广西自然科学基金(2016GXNSFAA380207);广西高校科学技术研究项目(KY2015LX510)

Anti-inflammatory and Analgesia Effects of Alcohol Extract from Barks of Shima superba

DENG Zhiyong, LUO Haiyu, CHEN Chaoying, DENG Yecheng*,SUN Wenbin, LIANG Fangming   

  1. College of Life Science, Guangxi Normal University, Guilin Guangxi 541006, China
  • Received:2017-09-25 Online:2019-01-20 Published:2019-01-08

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摘要： 分别采用醋酸扭体法、二甲苯致小鼠耳廓肿胀法、热板致痛法观察木荷Shima superba树皮乙醇提取物对小鼠的镇痛及抗炎作用。结果表明:1)木荷树皮乙醇提取物能够有效地抑制醋酸引起的小鼠镇痛扭体反应。其200 mg·kg-1处理组、400 mg·kg-1处理组、800 mg·kg-1处理组对小鼠的镇痛率分别为37.9%、52.2%和66.7%,阿司匹林200 mg·kg-1处理组的镇痛率为37.4%。2)木荷树皮乙醇提取物能够降低二甲苯引起的小鼠耳廓肿胀。其200 mg·kg-1处理组、400 mg·kg-1处理组、800 mg·kg-1处理组对小鼠耳廓肿胀的抑制率分别为35.1%、56.8%和69.3%,阿司匹林200 mg·kg-1处理组的抑制率为54.9%。3)木荷树皮乙醇提取物能够提高热板致痛的小鼠痛阈值。其200 mg·kg-1处理组、400 mg·kg-1处理组、800 mg·kg-1处理组药后60 min,小鼠痛阈提高率分别为50.1%、63.3%和78.3%,阿司匹林200 mg·kg-1处理组的痛阈提高率为63.6%。可见木荷树皮乙醇提取物有明显的抗炎消肿、镇痛的作用。

关键词: 木荷, 镇痛, 抗炎, 扭体法, 耳廓肿胀法, 热板法

Abstract: Anti-inflammatory and analgesia effects were observed by methods of acetic acid writhing, ear edema induced by xylene and hot-plate respectively. The results showed that the alcohol extracts from barks of Shima superba could significantly inhibite the number of writhing induced by acetic acid. The rates of anti-inflammatory and analgesia effects of 3 groups which treated mice with extracts from barks of S. superba (200 mg·kg-1, 400 mg·kg-1, 800 mg·kg-1) were 37.9%, 52.2% and 66.7%. The rate of anti-inflammatory and analgesia effects of aspirin groups (200 mg·kg-1) was 37.4%. The alcohol extracts from barks of S. superba could reduce the ear edema induced by xylene. The rates of inhibition ear edema of 3 groups which treated mice with extracts from barks of S. superba (200 mg·kg-1, 400 mg·kg-1, 800 mg·kg-1) were 35.1%, 56.8% and 69.3%. The rate of inhibition ear edema of aspirin groups (200 mg·kg-1) was 54.9%. The alcohol extracts from barks of S. superba could significantly enhance the pain threshold on hot-plate in mice. The rates of enhance the pain threshold of 3 groups which treated mice with extracts from barks of S. superba (200 mg·kg-1, 400 mg·kg-1, 800 mg·kg-1) when 60 min after the last administration were 50.1%, 63.3% and 78.3%. The rate of enhance the pain threshold of aspirin groups (200 mg·kg-1) was 63.6%. So the alcohol extracts from barks of S. superba have obvious effect on anti-inflammatory and analgesia.

Key words: Shima superba Gardn. et Champ., anti-inflammatory, analgesia, writhing method, auricle tumefaction method, hot plate method

中图分类号: 

  • R285.5
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