Journal of Guangxi Normal University(Natural Science Edition) ›› 2023, Vol. 41 ›› Issue (4): 25-32.doi: 10.16088/j.issn.1001-6600.2022082501

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Research Progress on Molecular Mechanism of Total Flavones of Rhizoma drynariae Regulating Osteoporosis

LIANG Jian1, WU Liang2*, SU Rui1, SONG Quansheng2, CHEN Feihu1   

  1. 1. Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China;
    2. The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning Guangxi 530023, China
  • Received:2022-08-25 Revised:2022-10-13 Online:2023-07-25 Published:2023-09-06

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Abstract: Osteoporosis is a systemic metabolic bone disease that can cause reduced bone mass and increase the risk of fracture due to microstructural degradation. At present, western medicine treatment is often accompanied by more serious adverse reactions, which reduce patients’ compliance, thus affecting the treatment effect. Traditional Chinese medicine is characterized by small adverse reactions, multiple ways and multiple targets. Under the guidance of the theory of “the main kidney bone produces marrow”, it is found that Rhizoma drynariae repair has a role in treating osteoporosis.The total flavones of R. drynariae are the main active components of R. drynariae which play an anti-osteoporosis role. With the continuous in-depth study of the pharmacology of traditional Chinese medicine, the total flavones of R. drynariae can regulate the osteogenic proliferation, differentiation and apoptosis of bone cells from multiple links, promote bone formation, increase bone mass, and achieve the role of preventing and treating osteoporosis. The signaling pathways involved include Wnt/β-catenin signaling pathway, MAPK signaling pathway, OPG/RANKL/RANK signaling pathway, BMPs signaling pathway, PI3K/AKT/mTOR signaling pathway, etc. This article summarized the molecular mechanism of the total flavones of R. drynariae and its main active components in the prevention and treatment of osteoporosis in recent years, discussed the exact mechanism of the anti-osteoporosis effect of osteoporotic in vivo, and provided help for the research and development of new anti-osteoporosis drugs.

Key words: Rhizoma drynariae, flavones, active monomer, naringin, naringenin, osteoporosis, molecular mechanisms

CLC Number:  R285
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[2] BAI Defa, XU Xin, WANG Guochang. Review of Generalized Linear Models and Classification for Functional Data[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(1): 15 -29 .
[3] ZENG Qingfan, QIN Yongsong, LI Yufang. Empirical Likelihood Inference for a Class of Spatial Panel Data Models[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(1): 30 -42 .
[4] ZHANG Xilong, HAN Meng, CHEN Zhiqiang, WU Hongxin, LI Muhang. Survey of Ensemble Classification Methods for Complex Data Stream[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 1 -21 .
[5] TONG Lingchen, LI Qiang, YUE Pengpeng. Research Progress and Prospects of Karst Soil Organic Carbon Based on CiteSpace[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 22 -34 .
[6] WANG Dangshu, YI Jiaan, DONG Zhen, YANG Yaqiang, DENG Xuan. Research on Bridgeless Boost PFC Converter with Ripple Suppression Unit Based on Single Cycle Control[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 47 -57 .
[7] YU Siting, PENG Jingjing, PENG Zhenyun. Rank Constraint Least Square Symmetric Semidefinite Solutions and Its Optimal Approximation of the Matrix Equation[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 136 -144 .
[8] QIN Chengfu, MO Fenmei. Structure ofC3-and C4-Critical Graphs[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 145 -153 .
[9] YIN Yudong, KE Shanzhe, HUANG Jiayan, DENG Mengxiang, LIU Guanyan, CHENG Keguang. One-pot Generation of Allylated Products from Alcohols, Carboxylic Acids and Amines with 1,3-Dibromopropane by Sodium Hydride[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 154 -161 .
[10] DU Libo, LI Jinyu, ZHANG Xiao, LI Yonghong, PAN Weidong. Chemical Constituents and Biological Activity from the Bark of Toona ciliata var. pubescens[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(4): 162 -172 .
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