骨碎补总黄酮调控骨质疏松症分子机制研究进展

doi:10.16088/j.issn.1001-6600.2022082501

Abstract

Abstract: Osteoporosis is a systemic metabolic bone disease that can cause reduced bone mass and increase the risk of fracture due to microstructural degradation. At present, western medicine treatment is often accompanied by more serious adverse reactions, which reduce patients’ compliance, thus affecting the treatment effect. Traditional Chinese medicine is characterized by small adverse reactions, multiple ways and multiple targets. Under the guidance of the theory of “the main kidney bone produces marrow”, it is found that Rhizoma drynariae repair has a role in treating osteoporosis.The total flavones of R. drynariae are the main active components of R. drynariae which play an anti-osteoporosis role. With the continuous in-depth study of the pharmacology of traditional Chinese medicine, the total flavones of R. drynariae can regulate the osteogenic proliferation, differentiation and apoptosis of bone cells from multiple links, promote bone formation, increase bone mass, and achieve the role of preventing and treating osteoporosis. The signaling pathways involved include Wnt/β-catenin signaling pathway, MAPK signaling pathway, OPG/RANKL/RANK signaling pathway, BMPs signaling pathway, PI3K/AKT/mTOR signaling pathway, etc. This article summarized the molecular mechanism of the total flavones of R. drynariae and its main active components in the prevention and treatment of osteoporosis in recent years, discussed the exact mechanism of the anti-osteoporosis effect of osteoporotic in vivo, and provided help for the research and development of new anti-osteoporosis drugs.

Key words: Rhizoma drynariae, flavones, active monomer, naringin, naringenin, osteoporosis, molecular mechanisms

CLC Number: R285

LIANG Jian, WU Liang, SU Rui, SONG Quansheng, CHEN Feihu. Research Progress on Molecular Mechanism of Total Flavones of Rhizoma drynariae Regulating Osteoporosis[J].Journal of Guangxi Normal University(Natural Science Edition), 2023, 41(4): 25-32.

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Research Progress on Molecular Mechanism of Total Flavones of Rhizoma drynariae Regulating Osteoporosis

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[2]	CHEN Yao, LI Meishan, QIN Feng, WANG Hengshan. Research Progress on Chemical Components and Pharmacological Effects of Zanthoxylum nitidum (Roxb.) DC. in Recent Five Years [J]. Journal of Guangxi Normal University(Natural Science Edition), 2023, 41(1): 24-37.
[3]	LIANG Linpan, LING Xue, FANG Jiao, SU Zhiheng, ZHENG Hua. Mechanism of Rubus suavissmus S. Lee in Intervention of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking Method [J]. Journal of Guangxi Normal University(Natural Science Edition), 2023, 41(1): 143-154.
[4]	LÜ Jiahua, ZHU Chan, TANG Zongxiang. Formation Mechanism and Biological Significance of Bitterness in Traditional Chinese Medicine [J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(5): 324-331.
[5]	JIANG Xianghui, TAN Rong, YANG Yongping, XIAO Qingzong. Analysis of Network Pharmacology and Confirmation of Mahonia fortunei (Lindl. ) Fedde and Glycyrrhiza uralensis Fisch Decoction for Hepatitis [J]. Journal of Guangxi Normal University(Natural Science Edition), 2021, 39(5): 198-209.
[6]	DENG Zhiyong, LUO Haiyu, CHEN Chaoying, DENG Yecheng,SUN Wenbin, LIANG Fangming. Anti-inflammatory and Analgesia Effects of Alcohol Extract from Barks of Shima superba [J]. Journal of Guangxi Normal University(Natural Science Edition), 2019, 37(1): 181-186.
[7]	NIE Yingtao,PENG Fenglin,LI Shaojie,WANG Ziwei,OU Chan. Effect of Polysaccharides of the Euphoria Longan (Lour.) Steudin Antifatigue by Reducing the Level of Oxygen Free Radicals [J]. Journal of Guangxi Normal University(Natural Science Edition), 2017, 35(3): 157-161.
[8]	YU Sheng, DUAN Si-liang, LI Hai-ye, HUANG Fu-ping. Effects of Extracts from Aspongopus chinensis Dallas on Cancer Cells [J]. Journal of Guangxi Normal University(Natural Science Edition), 2015, 33(1): 104-108.
[9]	HUANG Dong, LI Yuelin, BU Kai, HUANG Wen, MO Weibin. Effects of Glycyrrhiza Flavonoids on Lipid Metabolism Enzymeand Expression of ERRα mRNA and Protein of Exhaustive Rats [J]. Journal of Guangxi Normal University(Natural Science Edition), 2016, 34(1): 168-173.