半边旗中一个新的蕨素倍半萜

doi:10.16088/j.issn.1001-6600.2025112601

Abstract

Abstract: A phytochemical investigation of the ethanolic extract of Pteris semipinnata L. resulted in the isolation of eight terpenoids. The isolation was performed using a combination of chromatographic techniques, including silica gel, Sephadex LH-20, and semi-preparative HPLC. Structural elucidation was accomplished through comprehensive spectroscopic analysis, encompassing MS, 1D and 2D NMR, polarimetry, and electronic circular dichroism (ECD). The compounds were identified as (2R,3R)-14-norpterosin L(1), norpterosin C(2), norpterosin B(3), pterosin B(4), spelosin 3-O-β-D-glucopyranoside (5), 9-hydroxy-15-oxo-ent-kaur-16-en-18-oic acid (6), ent-(4α,11α)-11-hydroxy-15-oxo-kaur-16-en-18-oic acid (7), and ent-(7α,9α)-dihydroxy-kaur-16-en-19-oic acid (8). Compound1 was determined to be a new pterosin sesquiterpenoid, and compounds 5 and8 represent the first report of these constituents from this species. The isolated constituents were evaluated forin vitro antiproliferative activity with the MTS colorimetric assay against a five-member human tumour cell-line panel, and compounds 6 and7 possessed varying degrees of activity.

Key words: Pteris semipinnata L., Pteridaceae, pterosin sesquiterpenoid, kaurane diterpenoids, antitumor

CLC Number: R284

Li Min, Huang Chenghong, Liu Bingfei, Li Wenxia, Zhong Jinming, Wu Tinghao, Wei Anna, LuRumei, Liao Guangfeng. A new pterosin sesquiterpenoid from Pteris semipinnata L[J].Journal of Guangxi Normal University(Natural Science Edition), 2026, 44(6): 156-162.

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A new pterosin sesquiterpenoid from Pteris semipinnata L

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