Journal of Guangxi Normal University(Natural Science Edition) ›› 2021, Vol. 39 ›› Issue (2): 132-138.doi: 10.16088/j.issn.1001-6600.2020011603
Previous Articles Next Articles
LIU Jingjing1,2, CHEN Zhuanxin1,2, YOU Jiahang1,2, HUANG Jiayan1,2, CHENG Keguang1,2*
CLC Number:
[1] 种连娥,廖慧敏,王海燕,等.非布索坦的合成工艺研究[J].中国药物化学杂志,2014,24(4):303-306. [2] 刘小卒,刘培均,袁泽利,等.抗痛风药非布索坦的合成[J].精细化工,2014,31(6):745-748. [3] 潘洁玉.对羟基苯甲腈生产工艺的研究与开发[D].西安:西北大学,2012. [4] 刘泽,胡博,李珊,等.4-羟基苯甲腈的合成[J].精细化工中间体,2017,47(1):60-62. [5] 王勤,邱凌,宋康康,等.对氰基苯酚对蘑菇酪氨酸酶的抑制作用[J].厦门大学学报(自然科学版),2004,43(4):568-571. [6] 王喆,赵宏涛.羟基苯甲腈类抑制剂与Cdc25B磷酸酯酶相互作用的结合位点残基观察[J].山东医药,2015,55(23):18-20. [7] LUND G,DUDKIN S,BORKIN D,et al.Inhibition of CDC25B phosphatase through disruption of protein-protein interaction[J].ACS Chemical Biology,2015,10(2):390-394. [8] 陈晔,丁晨晨,郭志军,等.五环三萜类化合物药理活性研究进展[J].武警后勤学院学报(医学版),2017,26(12):1083-1087. [9] ZHU M,DU X N,LI Y G,et al.Design,synthesis and biological evaluation of novel HIV-1 protease inhibitors with pentacyclic triterpenoids as P2-ligands[J].Bioorganic and Medicinal Chemistry Letters,2019,29(3):357-361. [10] 刘蒲,王国权.五环三萜类化合物的药理作用研究进展[J].海峡药学,2018,30(10):1-6. [11] SALVADOR J A R,LEAL A S,VALDEIRA A S,et al.Oleanane-,ursane-,and quinone methide friedelane-type triterpenoid derivatives:Recent advances in cancer treatment[J].European Journal of Medicinal Chemistry,2017,142:95-130. [12] WANG H Z,ZHONG W L,ZHAO J M,et al.Oleanolic acid inhibits epithelial-mesenchymal transition of hepatocellular carcinoma by promoting iNOS dimerization[J].Molecular Cancer Therapeutics,2019,18(1):62-74. [13] 张明发,沈雅琴.熊果酸和齐墩果酸抗脑瘤作用的研究进展[J].药物评价研究,2016,39(1):132-135. [14] GUO J L,HAN T,BAO L,et al.Ursolic acid promotes the apoptosis of cervical cancer cells by regulating endoplasmic reticulum stress[J].Journal of Obstetrics and Gynaecology Research,2019,45(4):877-881. [15] CHEN J,ZHANG Z Q,SONG J,et al.18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma[J].Scientific Reports,2018,8:9365. [16] WANG S S,SHEN Y,QIU R F,et al.18β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration[J].International Journal of Oncology,2017,51(2):615-624. [17] SPIVAK A,KHALITOVA R,NEDOPEKINA D,et al.Synthesis and evaluation of anticancer activities of novel C-28 guanidine-functionalized triterpene acid derivatives[J].Molecules,2018,23(11):3000. [18] WANG R,LI Y,HUAI X D,et al.Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties[J].Drug Design Development and Therapy,2018,12:1321-1336. [19] LIN Y Y,CHAN S H,JUANG Y P,et al.Design,synthesis and cytotoxic activity of N-modified oleanolic saponins bearing a glucosamine[J].European Journal of Medicinal Chemistry,2018,143:1942-1958. [20] CHEN Y H,HOU X Y,ZHI D F,et al.Synthesis,characterization and anticancer activity of oleanolic acid and ursolic acid derivatives[J].Chinese Journal of Organic Chemistry,2016,36(4):795-802. [21] WANG W Z,LEI L,LIU Z,et al.Design,synthesis,and biological evaluation of novel nitrogen heterocycle-containing ursolic acid analogs as antitumor agents[J].Molecules,2019,24(5):877. [22] SUN H,YUE P Y K,WANG S R,et al.Synthesis and biological evaluations of cytotoxic and antiangiogenic triterpenoids-jacaranone conjugates[J].Medicinal Chemistry (Sharjah,United Arab Emirates),2016,12(8):775-785. [23] JIN L,DAI L M,JI M,et al.Mitochondria-targeted triphenylphosphonium conjugated glycyrrhetinic acid derivatives as potent anticancer drugs[J].Bioorganic Chemistry,2019,85:179-190. [24] JIN L,HUANG R Z,HUANG X C,et al.Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance[J].Bioorganic and Medicinal Chemistry,2018,26(8):1759-1775. [25] 孙立,初相伍,刘春梅,等.熊果酸/甘草次酸-尿嘧啶核苷缀合物的合成与抗肿瘤活性评价[J].广西师范大学学报(自然科学版),2020,38(1):87-92. [26] CHENG K G,SU C H,YANG L D,et al.Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity[J].European Journal of Medicinal Chemistry,2015,89:480-489. [27] CHENG K G,SU C H,HUANG J Y,et al.Synthesis and cytotoxic evaluation of several oleanolic acid-uracil/thymine conjugates[J].Medicinal Chemistry Communication,2016,7(5):972-981. [28] CHENG K G,SU C H,HUANG J Y,et al.Conjugation of uridine with oleanolic acid derivatives as potential antitumor agents[J].Chemical Biology and Drug Design,2016,88(3):329-340. [29] MALLAVADHANI U V,MAHAPATRA A,PATTNAIK B,et al.Synthesis and anti-cancer activity of some novel C-17 analogs of ursolic and oleanolic acids[J].Medicinal Chemistry Research,2013,22(3):1263-1269. [30] HUANG J Y,YANG L D,SU C H,et al.Synthesis and cytotoxicity evaluation of pentacyclic triterpene-phenol nitrogen mustard conjugates[J].Chemistry of Natural Compounds,2018,54(1):106-111. [31] SCHWARZ S,LUCAS S D,SOMMERWERK S,et al.Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases[J].Bioorganic and Medicinal Chemistry,2014,22(13):3370-3378. [32] MOSMANN T.Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays[J].Journal of Immunological Methods,1983,65(1/2):55-63. |
[1] | SUN Li, CHU Xiangwu, LIU Chunmei, ZHANG Juzheng, CHENG Keguang. Synthesis and Anti-tumor Activities of Ursolic Acid and Glycyrrhetinic Acid-Uridine Conjugates [J]. Journal of Guangxi Normal University(Natural Science Edition), 2020, 38(1): 87-92. |
[2] | LIU Xi. Antioxidant and Antitumor Activities of Extracts from Taxus chinensis var. mairei [J]. Journal of Guangxi Normal University(Natural Science Edition), 2016, 34(4): 55-59. |
[3] | HUANG Wanyun , YIN Penglong , LI Hong , PENG Xiangyan , SU Guifa. Synthesis and Antitumor, Antibacterial ActivityEvaluation of Ferrocene-quinolone Hybrids [J]. Journal of Guangxi Normal University(Natural Science Edition), 2016, 34(2): 111-115. |
[4] | HUO Hong-yue, LI Zhong-qing, QIN Qi-pin, LIU Yan-cheng, CHEN Zhen-feng. Crystal Structure and Antitumor Activity of Zinc(Ⅱ) Complex with Schiff Bases Derived from 2-Hydroxy-3-methoxybenzaldehyde and 2-(3,4-Methylenedioxyphenyl) ethylamine [J]. Journal of Guangxi Normal University(Natural Science Edition), 2014, 32(3): 65-73. |
[5] | CHEN Si-yuan, YANG Yang, PENG Yan, LIU Yan-cheng. Crystal Structure and Antitumor Activity of a New Schiff Base Palladium Complex [J]. Journal of Guangxi Normal University(Natural Science Edition), 2013, 31(2): 81-86. |
|