Journal of Guangxi Normal University(Natural Science Edition) ›› 2026, Vol. 44 ›› Issue (2): 1-16.doi: 10.16088/j.issn.1001-6600.2025051801

• Review •     Next Articles

Research Progress of New C21 Steroids in Medicinal Plants of Asclepiadaceae(Ⅱ)

XU Xiuhong, ZHANG Jinyan, LU Yuling, LIANG Xiaoping, LIAO Guangfeng, LU Rumei*   

  1. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China
  • Received:2025-05-18 Revised:2025-06-16 Published:2026-02-03

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Abstract: C21 steroids are a class of steroid derivatives containing 21 carbon atoms in the parent nucleus. They have many pharmacological activities such as anti-tumor, immune enhancement, anti-oxidation, anti-epilepsy, and hypolipidemic, and demonstrating significant medicinal value. Asclepiadaceae plants are one of the main sources of natural C21 steroids. According to the relevant literature, nearly 913 new C21 steroidal compounds were isolated from Asclepiadaceae in the past 20 years. According to the number, properties and degree of unsaturation of the substituents on the skeleton, their structures were divided into 9 types (I-IX), of which type I was pregnane and type II-IX was deformed pregnane. Pregnane and deformed pregnane differ in spatial structure, biological activity and metabolic pathway, which makes deformed pregnane become the focus of drug development and chemical biology research. In this paper, the distribution, physicochemical properties and spectral characteristics of type II-IX modified pregnane were introduced.

Key words: Asclepiadaceae, pregnane, structural characteristics, physicochemical property

CLC Number:  R284;O629
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