Journal of Guangxi Normal University(Natural Science Edition) ›› 2011, Vol. 29 ›› Issue (2): 56-60.

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Synthesis and Crystal Structure of Conformationally Constrained Peptides with a Trans-2,3-diaryl-1-aminocyclopropanecarboxylic Acid Residue

HUANG Wan-yun1, SU Gui-fa1, PAN Cheng-xue1, QIN Jiang-ke1, TANG Huang1, YI Xiang-hui2   

  1. 1.State Key Laboratory Cultivation Base for the Chemistry andMolecular Engineering of Medicinal Resources, College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.Department of Chemistry and Chemical Engineering,Guilin Normal College,Guilin Guangxi 541001,China
  • Received:2011-03-21 Published:2018-11-19

Abstract: Two diastereomers of conformationally constrained dipeptides with a trans-2,3-diaryl-1-aminocyclopropanecarboxylic acid residue were synthesized from L-Phenylalanine methyl ester and racemic 1-(4-Methoxy-phenyl)-2,5-diphenyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one utilized the oxazolone method,and the structures of them were studied by means of X-ray single crystal diffraction analysis.

Key words: conformationally constrained peptide, oxazolone method, synthesis, crystal structure

CLC Number: 

  • O629.72
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