Journal of Guangxi Normal University(Natural Science Edition) ›› 2026, Vol. 44 ›› Issue (6): 146-155.doi: 10.16088/j.issn.1001-6600.2025112003

• Medicinal Resources Research • Previous Articles     Next Articles

Secondary metabolites of an endophytic fungus Talaromyces sp. from Ardisia mamillata Hance and their antibacterial and antifungal activities

Wu Qian1,2,3,4, Tang Haimei1,2,3,4, Zhi Zhuojian1,2,3,4, Chen Xing1,2,3,4, Wang Wenli1,2,3,4, Cao Yuezhi1,2,3,4, RenJiahui1,2,3,4, Xu Weifeng1,2,3,4, Yang Ruiyun1,2,3,4*   

  1. 1. Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education of China (Guangxi Normal University), Guilin Guangxi 541004, China;
    2. Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
    3. Guangxi University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
    4. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2025-11-20 Revised:2026-01-22 Online:2026-11-05 Published:2026-11-10

Abstract: This study investigated the secondary metabolites of the endophyticfungus Talaromyces sp. HSHL-F40 isolated from Ardisia mamillata Hance and their antibacterial and antifungal activities. Seventeen compounds were isolated from the rice fermentation of the fungus by using column chromatography and semi-preparative HPLC. Their structures were identified as(2E,5E)-4-oxo-2-propylidene-5,7-octadienoic acid(1), peniciisocoumarin H (2), penicimarin C (3), penicilloxalone B (4), (R)-3-((3S, 4S)-3, 4-dihydroxypentyl)-8-hydroxyisochroman-1-one (5), (R)-3-((R)-4, 5-dihydroxypentyl)-8-hydroxyisochroman-1-one (6), talaroisocoumarin A (7), peniciisocoumarin F (8), aspergillumarins B (9), aspergillumarin A (10), (3S, 4S)-sclerotinin A (11), 3-(hydroxymethyl)-6, 8-dimethoxy-2H-1-benzopyran-2-one (12), talarohydrazone B(13), sequoiamonascin C (14), vermistatin (15), 4-hydroxy-2-methoxyacetanilide (16), and (E)-3-(2, 5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (17), by using NMR and HR-ESI-MS. Among these, compound 1 is a new compound, and the other compounds were isolated from the endophytic fungi of Ardisia mamillata Hance for the first time. Compound13 exhibited antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Bacillus megaterium, with MIC values of 8 mg/L. Antifungal assays revealed that compound 1 showed moderate inhibitory activity against Colletotrichum fructicola, with an MIC value of 32 mg/L.

Key words: Ardisia mamillata Hance, endophytic fungi, Talaromyces sp., secondary metabolites, antibacterial and antifungal activity

CLC Number:  O629.9
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