广西师范大学学报（自然科学版） ›› 2013, Vol. 31 ›› Issue (2): 81-86.

• • 上一篇    下一篇

一种新型希夫碱钯配合物的晶体结构及抗肿瘤活性研究

陈思园1,2, 杨扬1,2, 彭艳1,2, 刘延成1,2   

  1. 1.广西师范大学化学化工学院,广西桂林541004;
    2.广西师范大学药用资源化学与药物分子工程国家重点实验室培育基地,广西桂林541004
  • 收稿日期:2012-09-15 出版日期:2013-06-20 发布日期:2018-11-26
  • 通讯作者: 刘延成(1977—),男,河北文安人,广西师范大学副教授,博士。E-mail:ycliugxnu@aliyun.com
  • 基金资助:
    国家自然科学基金资助项目(21271051);广西医药产业人才小高地项目(1108);药用资源化学与药物分子工程教育部重点实验室自主研究项目(CMEMR2012-A11)

Crystal Structure and Antitumor Activity of a New Schiff Base Palladium Complex

CHEN Si-yuan1,2, YANG Yang1,2, PENG Yan1,2, LIU Yan-cheng1,2   

  1. 1.College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Guilin Guangxi 541004,China
  • Received:2012-09-15 Online:2013-06-20 Published:2018-11-26

摘要： 以自行合成的一种新型希夫碱——胡椒乙胺缩吡啶-2-甲醛(L)作为有机配体,与PdCl2配位反应合成一种希夫碱-钯(Ⅱ)配合物[PdCl2L](1)。通过红外光谱、元素分析和电喷雾质谱对配合物1进行结构表征,用X射线单晶衍射分析确定其晶体结构。通过MTT法测定了配合物1对5种人肿瘤细胞株的体外抗肿瘤活性,结果显示配合物1对人乳腺癌细胞MDA-MB-231有较好的增殖抑制活性,其IC50为(6.98±1.43) μmol/L,对其他4种肿瘤株的抑制活性则较低,表明配合物1对于不同肿瘤细胞表现一定的毒性选择性,表现出潜在的抗肿瘤药用前景。

关键词: 希夫碱, 钯(Ⅱ)配合物, 晶体结构, 抗肿瘤活性

Abstract: A new Schiff base 3,4-methylenedioxy-phenethylamine-pyridine-2-formaldehyde (L),was synthesized as ligand.The reaction of L with PdCl2 afforded the first palladium(Ⅱ) complex of L (complex 1).Complex 1 was characterized by IR,elemental analysis,ESI-MS,and structurally determined by X-ray single crystal diffraction analysis.In vitro cytotoxicity test against six human tumor cell lines by MTT method showed that complex 1exhibited significant cytotoxicity against the MDA-MB-231 tumor cell,with IC50 value of (6.98±1.43) μmol/L,while low cytotoxicity to the other fivetumor cell lines (including A549,HeLa,NCI-H460,MGC80-3 and BEL7404),which indicatedthat complex 1 showed some cytotoxic selectivity on these tested tumor cell lines,suggesting its potential for the antitumoral applications.

Key words: Schiff base, palladium(Ⅱ) complex, crystal structure, antitumor activity

中图分类号: 

  • O641.4
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