超声介导药物递送研究进展

doi:10.16088/j.issn.1001-6600.2022012804

摘要/Abstract

摘要： 如何实现药物靶向高效递送是目前的研究热点。超声具有无创、无辐射、操作简单、价格低廉等优点,临床诊断利用了超声波的反射、折射和衍射原理。由于具有机械效应和热效应,超声也是一种高效的药物控释外源性刺激方法,可以提高病变组织和细胞膜的通透性,促进细胞对药物的摄取,在此基础上发展的超声介导药物递送系统,已经成为一种高效、无创的递送技术。通过超声辐照肿瘤区域,实现药物的定点定量释放,提高局部药物浓度,改善疗效。超声联合各类载体,诸如超声微泡、脂质体等在药物靶向递送方面具有极大的临床转化价值。本文从超声增强药物递送机制、超声响应载体、超声增强药物递送效果及其临床应用前景等方面进行综述。

关键词: 超声, 药物递送, 微纳米材料, 超声分子影像, 靶向治疗, 临床应用

Abstract: How to achieve efficient and targeted drug delivery is a current research hotspot. Ultrasound has the advantages of non-invasiveness, non-radiation, simple operation and low price. Clinical diagnosis uses the principles of reflection, refraction and diffraction of ultrasound. Attributed to its mechanical and thermal effects, ultrasound is also an efficient exogenous stimulation method for controlling drug release, which can improve the permeability of diseased tissues and cell membranes, and promote the uptake of drugs by cells. On this basis, the ultrasound mediated drug delivery has become an efficient and noninvasive delivery technology. The targeted and quantitative release of drugs can be realized by irradiating the tumor area with ultrasound, so as to increase the local drug concentration and thus improve the curative effect. Ultrasound combined with various carriers, such as ultrasonic microbubbles, liposomes and so on, has great clinical translation value in drug targeted delivery. This article will review ultrasound-enhanced drug delivery mechanism, ultrasound responsive carriers, the effect of ultrasound-enhanced drug delivery and its clinical application prospects.

Key words: ultrasound, drug delivery, micro-nano materials, ultrasound molecular imaging, targeted therapy, clinical application

中图分类号:

R943

吴睿麒, 梁晓龙. 超声介导药物递送研究进展[J]. 广西师范大学学报（自然科学版）, 2022, 40(5): 271-285.

WU Ruiqi, LIANG Xiaolong. Research Advances in Ultrasound Mediated Drug Delivery[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(5): 271-285.

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