广西师范大学学报（自然科学版） ›› 2022, Vol. 40 ›› Issue (5): 227-252.doi: 10.16088/j.issn.1001-6600.2022030804

• 综述 • 上一篇    下一篇

青钱柳的化学成分及药理活性研究进展

李俊1,2,3*, 梁晓琴1,2,3, 常燕玲1,2,3, 黄艳1,2,3, 潘立卫1,2,3   

  1. 1.广西师范大学 化学与药学学院, 广西 桂林 541004;
    2.省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学), 广西 桂林 541004;
    3.广西民族药省部共建协同创新中心(广西师范大学), 广西 桂林 541004
  • 收稿日期:2022-03-08 修回日期:2022-04-20 出版日期:2022-09-25 发布日期:2022-10-18
  • 通讯作者: 李俊(1964—), 男, 广西浦北人, 广西师范大学教授, 博导。E-mail: lijun9593@gxnu.edu.cn
  • 基金资助:
    国家自然科学基金(32060097); 广西自然科学基金(2018GXNSFDA050007, 2018GXNSFAA050042)

Review on the Constituents and Pharmacological Activities of Cyclocarya paliurus

LI Jun1,2,3*, LIANG Xiaoqin1,2,3, CHANG Yanling1,2,3, HUANG Yan1,2,3, PAN Liwei1,2,3   

  1. 1. School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin Guangxi 541004, China;
    2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin Guangxi 541004, China;
    3. Collaborative Innovation Center for Guangxi Ethnic Medicine (Guangxi Normal University), Guilin Guangxi 541004, China
  • Received:2022-03-08 Revised:2022-04-20 Online:2022-09-25 Published:2022-10-18

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摘要： 青钱柳Cyclocarya paliurus (Batal) Iljinskaja为胡桃科Juglandaceae青钱柳属Cyclocarya植物,该植物属于自然界较为少见的单种属植物。青钱柳为我国特有的药食两用植物,广泛分布于我国南方多个省份,不仅含有人体所必须的常量矿物质,而且还含有对人体有重要保健功能的微量矿物质;主要有机成分为三萜类、黄酮类、多糖类、苯丙酸类等化合物。研究表明,青钱柳具有降血糖、降血脂、抗炎、减肥、抗肿瘤、提高免疫力等多种药理作用。本文对近年来有关青钱柳的化学成分和药理活性研究进行综述,以期为后续研究、开发和利用该植物提供参考。

关键词: 青钱柳, 青钱柳属, 青钱柳苷, 青钱苷, 降血糖, 降血脂

Abstract: Cyclocarya paliurus (Batal) Iljinskaja, belonging to the genus Cyclocarya (Juglandaceae), consists only one species distributed in south China. C. paliurus leaves are used in traditional medicine for a long history. It contains the inorganic constant and trace components required by the human body, and it is a selenium-rich plant product. More than 240 compounds, including dammarane triterpenoids, oleanane triterpenoids, ursane triterpenoids, lupinane triterpenoids, flavonoids, isosclerones, phenolic derivatives, and polysaccharides, etc, have been separated from C. paliurus. Among them, 3,4-seco-dammarane triterpenoids are the most abundant and the most characteristic. Furthermore, the extracts and compounds from C. paliurus have been found to exert various pharmacological activities, such as anti-hyperglycemic, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, cytotoxic activities. Although great breakthroughs during the past 30 years years have been made in the research of the pharmacology and constituents of C. paliurus, the research and development of drugs related to C. paliurus has lagged behind seriously. The systematic and in-depth research is still needed in the toxicity and development of C. paliurus. The present review summarizes the constituents and pharmacological activity of C. paliurus to provide reference for further research, development and utilization of this plant.

Key words: Cyclocarya paliurus (Batal) Iljinskaja, Cyclocarya, cyclocarioside, cypaliuruside, hypoglycemia, hypolipidemia

中图分类号: 

  • O629
[1]中国科学院中国植物志编辑委员会. 中国植物志(第21卷)[M]. 北京: 科学出版社, 1979: 19.
[2]国家中医药管理局《中华本草》编委会. 中华本草(第5卷)[M]. 上海: 上海科学技术出版社, 1999: 370.
[3]谢宗万. 全国中草药汇编(下册)[M].2版. 北京: 人民卫生出版社, 1996: 802.
[4]国家卫生与计划生育委员会公告. 裸藻等8种新食品原料(2013年第4号)[EB]. 2013, 124: 4.
[5]李磊, 谢明勇,吴熙鸿,等. 胡桃科植物青钱柳多种微量元素的化学形态研究[J]. 江西农业大学学报, 1999, 21(4): 546-551.
[6]李磊, 谢明勇, 郑泽元. 青钱柳无机元素的初级形态分析[J]. 南昌大学学报(工科版), 2000, 22(1): 74-77,87.
[7]李磊, 谢明勇, 吴熙鸿, 等. MAP-ICP-MS测定保健食品青钱柳及其浸提物中多种矿质营养素的研究[J]. 食品科学, 2000, 21(2): 53-57.
[8]苑静, 蒋向辉. 不同消解方法对检测青钱柳叶中钒元素的影响[J]. 湖北农业科学, 2015, 54(18): 4585-4587. DOI: 10.14088/j.cnki.issn0439-8114.2015.18.049.
[9]邓佑林, 彭继升, 李芳, 等. 青钱柳中黄酮成分提取工艺的优化及微量元素分析[J]. 化工技术与开发, 2016, 45(4): 1-4. DOI: 10.3969/j.issn.1671-9905.2016.04.001.
[10]王庆, 邱彬, 王俊杰, 等. 微波消解ICP-MS法测定青钱柳叶和茶汤中29种元素[J]. 湘南学院学报, 2017, 38(5): 22-26. DOI: 10.3969/j.issn.1672-8173.2017.05.005.
[11]李磊, 赵丽, 谢明勇, 等. 青钱柳多糖组分生物活性及其元素化学形态分析[J]. 厦门大学学报(自然科学版), 2003, 42(1): 73-77. DOI:10.3321/j.issn:0438-0479.2003.01.017.
[12]XIE M Y, LI L, NIE S P,et al. Determination of speciation of elements related to blood sugar in bioactive extracts from Cyclocarya paliurus leaves by FIA-ICP-MS[J]. European Food Research and Technology, 2006, 223(2): 202-209. DOI:10.1007/s00217-005-0173-0.
[13]XIE J H, SHEN M Y, NIE S P, et al. Simultaneous analysis of 18 mineral elements in Cyclocarya paliurus polysaccharide by ICP-AES[J]. Carbohydrate Polymers, 2013, 94(1): 216-220. DOI: 10.1016/j.carbpol.2012.12.072.
[14]李磊, 谢明勇, 孙振华, 等. 青钱柳叶植物药中生命元素的溶出特性及其化学形态研究[J]. 高等学校化学学报, 2000, 21(5): 707-709. DOI: 10.3321/j.issn:0251-0790.2000.05.034.
[15]柏文恋, 袁丛军, 谢涛, 等. 黔产青钱柳叶片营养元素含量特征及变异规律[J]. 中南林业科技大学学报, 2022, 42(2): 36-45. DOI: 10.14067/j.cnki.1673-923x.2022.02.005.
[16]杨大坚, 钟炽昌, 谢昭明. 甜茶树甜味成分研究[J]. 药学学报, 1992, 27(11): 841-844. DOI: 10.16438/j.0513-4870.1992.11.008.
[17]舒任庚, 徐昌瑞, 黎莲娘. 青钱柳甜味成分的研究[J]. 药学学报, 1995, 30(10): 757-761. DOI: 10.16438/j.0513-4870.1995.10.008.
[18]SHU R G, XU C R, LI L N,et al. Cyclocariosides II and III: two seco-dammarane triterpenoid saponins from Cyclocarya paliurus[J]. Planta Medica, 1995, 61(6): 551-554. DOI: 10.1055/s-2006-959369.
[19]JIANG Z Y, ZHANG X M, ZHOU J, et al. Two new triterpenoid glycosides from Cyclocarya paliurus[J]. Journal of Asian Natural Products Research, 2006, 8(1/2): 93-98.
[20]LI S, CUI B D, LIU Q, et al. New triterpenoids from the leaves of Cyclocarya paliurus[J]. Planta Medica, 2012, 78(3): 290-296. DOI: 10.1055/s-0031-1280411.
[21]LIU Y, ZHANG M Q, LI X L, et al. Study on chemical constituents of Cyclocarya paliurus[J]. Journal of Asian Natural Products Research, 2014, 16(2): 206-209. DOI: 10.1080/10286020.2013.825254.
[22]CUI B S, LI S. New triterpenoid saponins from the leaves of Cyclocarya paliurus[J]. Chinese Chemical Letters, 2015, 26(5): 585-589. DOI: 10.1016/j.cclet.2014.11.033.
[23]WU Z F, MENG F C, CAO L J, et al. Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells[J]. Phytochemistry, 2017, 142: 76-84. DOI: 10.1016/j.phytochem.2017.06.015.
[24]SUN H H, TAN J, LV W Y, et al. Hypoglycemic triterpenoid glycosides from Cyclocarya paliurus (Sweet Tea Tree)[J]. Bioorganic Chemistry, 2020, 95: 103493. DOI: 10.1016/j.bioorg.2019.103493.
[25]YAN H, LI X, NI W, et al. Phytochemicals from the leaves of Cyclocarya paliurus and their 11β-HSD1 enzyme inhibitory effects[J]. Chemistry and Biodiversity, 2021, 18(1): e2000772. DOI: 10.1002/cbdv.202000772.
[26]WANG Y R, CUI B S, HAN S W, et al. New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus[J]. Journal of Asian Natural Products Research, 2018, 20(11): 1019-1027. DOI: 10.1080/10286020.2018.1457653.
[27]LI C G, DENG S P, LIU W, et al. α-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus[J]. Bioorganic Chemistry, 2021, 111: 104847. DOI: 10.1016/j.bioorg.2021.104847.
[28]PENG W W, ZHAO S M, JI C J, et al. Cyclopalitins A and B, nortriterpenoids from aerial parts of Cyclocarya paliurus [J]. Phytochemistry Letters, 2019, 31: 114-117. DOI: 10.1016/j.phytol.2019.03.017.
[29]ZHOU X L, LI S B, YAN M Q, et al. Bioactive dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus [J]. Phytochemistry, 2021, 183: 112618. DOI:10.1016/j.phytochem.2020.112618.
[30]ZHU L P, YANG H M, ZHENG X, et al. Four new dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus and their SIRT1 activation activities[J]. Fitoterapia, 2021, 154: 105003. DOI: 10.1016/j.fitote.2021.105003.
[31]KENNELLY E J, CAI L N, LONG L N, et al. Novel highly sweet seco-dammarane glycosides from Pterocarya puliurus[J]. Journal of Agricultural and Food Chemistry, 1995, 43(10): 2602-2607. DOI: 10.1021/jf00058a009.
[32]CHEN Y J, NA L, FAN J L, et al. Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus[J]. Phytochemistry, 2018, 145: 85-92. DOI: 10.1016/j.phytochem.2017.10.013.
[33]LIU W, DENG S P, ZHOU D X, et al. 3,4-seco-Dammarane triterpenoid saponins with anti-inflammatory activity isolated from the leaves of Cyclocarya paliurus[J]. Journal of Agricultural and Food Chemistry, 2020, 68(7): 2041-2053. DOI: 10.1021/acs.jafc.9b06898.
[34]SUN H H,LV W Y,TAN J, et al. Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus[J]. Natural Product Research, 2020, 35(21): 4018-4024. DOI:10.1080/14786419.2020.1756801.
[35]WU Y, LI Y Y, WU X, et al. Chemical constituents from Cyclocarya paliurus(Batal.) Iljinsk[J]. Biochemical Systematics and Ecology, 2014, 57: 216-220. DOI: 10.1016/j.bse.2014.08.022.
[36]FANG Z J, SHEN S N, WANG J M, et al. Triterpenoids from Cyclocarya paliurus that enhance glucose uptake in 3T3-L1 adipocytes[J]. Molecules, 2019, 24(1): 187. DOI: 10.3390/molecules24010187.
[37]XUAN T Y, TAN J, SUN H H, et al. Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus[J]. Natural Product Research, 2021, 35(1): 167-173. DOI: 10.1080/14786419.2019.1616722.
[38]LIU Y, ZHENG G T, ZHANG X X, et al. Two new triterpenoids from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja [J/OL]. Natural Product Research, [2022-03-08]. https://doi.org/10.1080/14786419.2021.1900845. DOI:10.1080/14786419.2021.1900845.
[39]钟瑞建, 舒任庚, 倪小兰, 等. 青钱柳酸A的结构研究[J]. 药学学报, 1996, 31(5): 398-400. DOI: 10.16438/j.0513-4870.1996.05.014.
[40]钟瑞建, 高幼衡, 徐昌瑞, 等. 青钱柳中五环三萜成分的研究[J]. 中草药, 1996, 27(7): 387-388.
[41]YANG H M, YIN Z Q, ZHAO M G, et al. Pentacyclic triterpenoids from Cyclocarya paliurus and their antioxidant activities in FFA-induced HepG2 steatosis cells[J]. Phytochemistry, 2018, 151: 119-127. DOI: 10.1016/j.phytochem.2018.03.010.
[42]舒任庚, 刘玉凤, 陈杰, 等. 青钱柳植物中三萜成分的研究[J]. 中药材, 2005, 28(7): 558-559. DOI: 10.3321/j.issn:1001-4454.2005.07.013.
[43]LI J, LU Y Y, SU X J, et al. A norsesquiterpene lactone and a benzoic acid derivative from leaves of Cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activities[J]. Planta Medica, 2008, 74(3): 287-289. DOI: 10.1055/s-2008-1034309.
[44]李俊, 黄锡山, 陆圆圆, 等. 青钱柳化学成分的研究[J]. 中成药, 2008, 30(2): 238-240.
[45]李田, 上官新晨, 尹忠平, 等. 青钱柳叶三萜化合物分离与鉴定[J]. 江西农业大学学报, 2013, 35(5): 1048-1054. DOI:10.13836/j.jjau.2013184.
[46]PENG W W, ZHANG Z Y, JI C J, et al. Chemical constituents from the aerial part of Cyclocarya paliurus (Batal.) Iljinsk (Juglandaceae)[J]. Biochemical Systematics and Ecology, 2018, 78: 110-112. DOI: 10.1016/j.bse.2018.04.012.
[47]李龙宇, 罗荣华, 徐明杰, 等. 青钱柳叶的化学成分研究[J]. 中国现代中药, 2021, 23(10): 1705-1709. DOI: 10.13313/j.issn.1673-4890.20201209005.
[48]YE Z J, HE X A, WU J P, et al. New prenylflavonol glycosides with xanthine oxidase inhibitory activity from the leaves of Cyclocarya paliurus[J]. Bioorganic Chemistry, 2020, 101: 104018. DOI: 10.1016/j.bioorg.2020.104018.
[49]YE Z J, SUN H H, CHEN Z H, et al. Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus[J]. Natural Product Research, 2022, 36(3): 772-779. DOI:10.1080/14786419.14782020.11803313.
[50]张晓, 廖循, 丁立生. 青钱柳的化学成分[J]. 应用与环境生物学报, 2001, 7(1): 90-91. DOI: 10.3321/j.issn:1006-687X.2001.01.021.
[51]李俊, 陆园园, 李甫, 等. 青钱柳化学成分的研究[J]. 中药材, 2006, 29(5): 441-442.
[52]李俊, 陆园园, 许子竞, 等. 青钱柳中黄酮成分的研究[J]. 中药材, 2005, 28(12): 1058-1059. DOI: 10.3321/j.issn:1001-4454.2005.12.006.
[53]LI S, LI J, GUAN X L, et al. Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase[J]. Fitoterapia, 2011, 82(7): 1081-1085. DOI: 10.1016/j.fitote.2011.07.002.
[54]张晓琦, 叶文才, 殷志琦, 等. 青钱柳的化学成分研究[J]. 中国中药杂志, 2005, 30(10): 791-792. DOI: 10.3321/j.issn:1001-5302.2005.10.022.
[55]张娟, 路金才, 肖凯, 等. 青钱柳水溶性成分的研究[J]. 药学实践杂志, 2007, 25(2): 82-84. DOI: 10.3969/j.issn.1006-0111.2007.02.006.
[56]ZHANG J, SHEN Q, LU J C, et al. Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B[J]. Food Chemistry, 2009, 119(4): 1491-1496. DOI: 10.1016/j.foodchem.2009.09.031.
[57]舒任庚, 宋子荣, 舒积成. 青钱柳正丁醇部位化学成分研究[J]. 中药材, 2006, 29(12): 1304-1307. DOI: 10.3321/j.issn:1001-4454.2006.12.017.
[58]易醒, 石建功, 周光雄, 等. 青钱柳化学成分研究[J]. 中国中药杂志, 2002, 27(1): 43-45. DOI: 10.3321/j.issn:1001-5302.2002.01.017.
[59]何艳, 殷志琦, 张健, 等. 青钱柳地上部分的化学成分研究[J]. 药学与临床研究, 2012, 20(3): 187-189.
[60]刘文斌, 董丽梅, 罗碧, 等. 青钱柳叶的化学成分研究[J]. 热带亚热带植物学报, 2018, 26(3): 317-322.
[61]欧徐涵, 况燚, 吴学谦, 等. 青钱柳叶子化学成分的研究[J]. 中草药, 2017, 48(23): 4840-4844. DOI: 10.7501/j.issn.0253-2670.2017.23.003.
[62]LIU Y, CHEN P, ZHOU M M, et al. Geographic variation in the chemical composition and antioxidant properties of phenolic compounds from Cyclocarya paliurus (Batal) Iljinskaja leaves[J]. Molecules, 2018, 23(10): 2440. DOI: 10.3390/molecules23102440.
[63]ZHOU X L, LUO Q, HUANG S X, et al. New tetralone derivatives from the leaves of Cyclocarya paliurus[J]. Journal of Asian Natural Products Research, 2019, 21(2): 157-164. DOI: 10.1080/10286020.2017.1409733.
[64]舒任庚, 徐昌瑞, 黎莲娘, 等. 青钱柳化学成分的研究(I)[J]. 中药材, 1995, 18(7): 351-352. DOI: 10.13863/j.issn1001-4454.1995.07.014.
[65]舒任庚, 徐昌瑞, 刘庆华, 等. 青钱柳化学成分的研究[J]. 中国中药杂志, 1995, 20(11): 680-681.
[66]段玉书, 胡永, 杨万霞, 等. 黔产青钱柳化学成分及α-葡萄糖苷酶抑制活性研究[J]. 天然产物研究与开发, 2019, 31: 940-945. DOI: 10.16333/j.1001-6880.2019.6.003.
[67]黎旭, 路金才, 张娟, 等. 青钱柳叶化学成分及其PTP1B抑制活性的研究[J]. 中南药学, 2016, 14(10): 1074-1078.
[68]舒任庚, 舒积成. 青钱柳中的酚类化学成分[J]. 中草药, 2007, 38(4): 507-508. DOI: 10.3321/j.issn:0253-2670.2007.04.010.
[69]LIANG L F, DU S N, HUANG K Y, et al. Preliminary study of terpenes from the leaves of Cyclocarya paliurus[J]. Chemistry of Natural Compounds, 2018, 54 (2): 382-383. DOI: 10.1007/s10600-018-2355-6.
[70]崔保松, 李帅. 青钱柳叶的化学成分研究[J]. 中草药, 2012, 43(11): 2132-2136.
[71]XIE J H, LIU X, SHEN M Y, et al. Purification, physi-cochemical characterisation and anticancer activity of a polysaccharide from Cyclocarya paliurus leaves[J]. Food Chemistry, 2013, 136(3/4): 1453-1460. DOI: 10.1016/j.foodchem.2012.09.078.
[72]XIE J H, SHEN M Y, NIE S P, et al. Separation of water-soluble polysaccharides from Cyclocarya paliurus by ultrafiltration process[J]. Carbohydrate Polymers, 2014, 101: 479-483. DOI: 10.1016/j.carbpol.2013.09.075.
[73]WANG Z J, XIE J H, SHEN M Y, et al. Carboxymethylation of polysaccharide from Cyclocarya paliurus and their characterization and antioxidant properties evaluation[J]. Carbohydrate Polymers, 2016, 136: 988-994. DOI: 10.1016/j.carbpol.2015.10.017.
[74]TANG W, LIN L H, XIE J H, et al. Effect of ultrasonic treatment on the physicochemical properties and antioxidant activities of polysaccharide from Cyclocarya paliurus[J]. Carbohydrate Polymers, 2016, 151: 305-312. DOI: 10.1016/j.carbpol.2016.05.078.
[75]王小江, 单鑫迪, 胡明华, 等. 青钱柳叶多糖的结构表征及其抑制α-葡萄糖苷酶活性研究[J]. 中草药, 2017, 48(8): 1524-1528. DOI: 10.7501/j.issn.0253-2670.2017.08.008.
[76]HU W B, ZHAO J, CHEN H, et al. Polysaccharides from Cyclocarya paliurus: chemical composition and lipid-lowering effect on rats challenged with high-fat diet[J]. Journal of Functional Foods, 2017, 36: 262-273. DOI: 10.1016/j.jff.2017.07.020.
[77]蒋向辉, 蒋天智, 王翔, 等. 青钱柳叶多糖中单糖组分分析[J]. 广西师范大学学报(自然科学版), 2018, 36(2): 87-93. DOI: 10.16088/j.issn.1001-6600.2018.02.012.
[78]WANG X J, ZHAO X L, LV Y J, et al. Extraction, isolation and structural characterization of a novel polysaccharide from Cyclocarya paliurus[J]. International Journal of Biological Macromolecules, 2019,132: 864-870. DOI: 10.1016/j.ijbiomac.2019.03.148.
[79]AN Q, YE X M, HAN Y, et al. Structure analysis of polysaccharides purified from Cyclocarya paliurus with DEAE-cellulose and its antioxidant activity in RAW264.7 cells[J]. International Journal of Biological Macromolecules, 2020, 157: 604-615. DOI: 10.1016/j.ijbiomac.2019.11.212.
[80]HAN Y, ZHAO M, OUYANG K H, et al. Sulfated modification, structures, antioxidant activities and mechanism of Cyclocarya paliurus polysaccharides protecting dendritic cells against oxidant stress[J]. Industrial Crops and Products, 2021, 164: 113353. DOI: 10.1016/j.indcrop.2021.113353.
[81]ZHAO M, HAN Y, LI J E, et al. Structural characterization and antioxidant activity of an acetylated Cyclocarya paliurus polysaccharide (Ac-CPP0.1)[J]. International Journal of Biological Macromolecules, 2021, 171: 112-122. DOI: 10.1016/j.ijbiomac.2020.12.201.
[82]WANG H, TANG C, GAO Z Z, et al. Potential role of natural plant medicine Cyclocarya paliurus in the treatment of type 2 diabetes mellitus[J]. Journal of Diabetes Research, 2021, 2021: 1655336.
[83]易醒, 谢明勇, 温辉梁, 等. 青钱柳对四氧嘧啶糖尿病小鼠降血糖作用的研究[J]. 天然产物研究与开发, 2001, 13(3): 52-54,57. DOI: 10.16333/j.1001-6880.2001.03.015.
[84]周琴, 伍学智, 石孟琼, 等. 青钱柳叶三萜对链脲佐菌素损伤INS-1细胞自噬和凋亡的影响[J]. 中药药理与临床, 2017, 33(1): 89-94. DOI: 10.13412/j.cnki.zyyl.2017.01.025.
[85]XIAO H T, WEN B, NING Z W, et al. Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis[J]. Scientific Reports, 2017, 7(1): 9155. DOI: https:10.1038/s41598-017-09641-z.
[86]彭红梅, 何小静, 陈金鑫, 等. 青钱柳提取物对实验性糖尿病小鼠降糖作用研究[J]. 四川中医, 2018, 36(12): 60-63.
[87]JIANG C H, WANG Y T, JIN Q M, et al. Cyclocarya paliurus triterpenoids improve diabetes-induced hepatic inflammation via the rho-kinase dependent pathway[J]. Frontiers in Pharmacology, 2019, 10: 811. DOI: 10.3389/fphar.2019.00811.
[88]ZHAO L C, WANG X, LI J X, et al. Effect of Cyclocarya paliurus on hypoglycemic effect in type 2 diabetic mice[J]. Medical Science Monitor, 2019, 25: 2976-2983. DOI: 10.12659/msm.913368.
[89]YOSHITOMI H, TSURU R, LI L Y, et al. Cyclocarya paliurus extract activates insulin signaling via sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion[J]. PLoS One, 2017, 12(8): e0183988. DOI: 10.1371/journal.pone.0183988.
[90]ZHANG X X, JIANG C H, LIU Y, et al. Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats[J]. Phytomedicine, 2019, 64: 153060/. DOI: 10.1016/j.phymed.2019.153060.
[91]ZHENG X, ZHAO M G, JIANG C H, et al. Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates insulin resistance and hepatic steatosis via PI3K/Akt/GSK3β pathway[J]. Phytomedicine, 2020, 66: 153130. DOI: 10.1016/j.phymed.2019.153130.
[92]WANG Y, ZHENG X J, LI L Y, et al. Cyclocarya paliurus ethanol leaf extracts protect against diabetic cardiomyopathy in db/db mice via regulating PI3K/Akt/NF-κB signaling[J]. Food and Nutrition Research, 2020, 64: 4267. DOI: 10.29219/fnr.v64.4267.
[93]秦帅, 秦灵灵, 吴丽丽, 等. 青钱柳对糖尿病小鼠肝脏糖脂代谢影响及机制研究[J]. 世界科学技术-中医药现代化, 2020, 22(10): 3443-3449. DOI: 10.11842/wst.20200507003.
[94]ZHAI L X, NING Z W, HUANG T, et al. Cyclocarya paliurus leaves tea improves dyslipidemia in diabetic mice: a lipidomics-based network pharmacology study[J]. Frontiers in Pharmacology, 2018, 9: 973. DOI: 10.3389/fphar.2018.00973.
[95]王依婷, 赵梦鸽, 盛雪萍, 等. 青钱柳三萜酸对高糖所致的胰岛α细胞胰岛素抵抗的影响[J]. 中国药科大学学报, 2018, 49(2): 215-221. DOI: 10.11665/j.issn.1000-5048.20180212.
[96]李楠, 赵静, 吴茹, 等. 青钱柳多糖对高脂血症大鼠脂代谢及对PPARα、FAS、GLUT4基因mRNA表达的影响[J]. 现代食品科技, 2015, 31(4): 29-35. DOI: 10.13982/j.mfst.1673-9078.2015.4.006.
[97]LI Q Q, HU J L, NIE Q X, et al. Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration[J]. Science China: Life Sciences, 2021, 64(1): 117-132. DOI:10.1007/s11427-019-1647-6.
[98]ZHU K N, JIANG C H, TIAN Y S, et al. Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation[J]. Phytomedicine, 2015, 22: 837-846. DOI: 10.1016/j.phymed.2015.05.058.
[99]LIN Z X, TONG Y P, LI N, et al. Network pharmacology-based study of the mechanisms of action of anti-diabetic triterpenoids from Cyclocarya paliurus[J]. RSC Advances, 2020, 10(61): 37168-37181. DOI: 10.1039/d0ra06846b.
[100]JIANG C H, WANG Q Q, WEI Y J, et al. Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice[J]. Journal of Ethnopharmacology, 2015, 176: 17-26. DOI: 10.1016/j.jep.2015.10.006.
[101]WU Z F, GAO T H, ZHONG R L, et al. Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats[J]. Pharmaceutical Biology, 2017,55(1): 712-721. DOI: 10.1080/13880209.2016.1267231.
[102]MA Y L, JIANG C H, YAO N, et al. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice[J]. Journal of Ethnopharmacology, 2015, 166: 286-296.
[103]YAO X M, LIN Z, JIANG C H, et al. Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague-Dawley rats[J]. Canadian Journal of Physiology and Pharmacology, 2015, 93(8): 677-686. DOI: 10.1139/cjpp-2014-0477.
[104]LIN Z, WU Z F, JIANG C H, et al. The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats[J]. Phytomedicine, 2016, 23(12): 1475-1483. DOI: 10.1016/j.phymed.2016.08.003.
[105]许光远, 孙文, 郭璇, 等. 青钱柳总皂苷对游离脂肪酸诱导的H4-IIE细胞脂肪代谢的影响及作用机制[J]. 中国实验方剂学杂志, 2017, 23(15): 124-129. DOI: 10.13422/j.cnki.syfjx.2017150124.
[106]叶振南, 李楠, 盛丹丹, 等. 青钱柳多糖对高脂血症大鼠血脂及抗脂质过氧化作用的影响[J]. 现代食品科技, 2014, 30(4): 1-5,20. DOI: 10.13982/j.mfst.1673-9078.2014.04.048.
[107]赵静, 吴茹, 李楠, 等. 青钱柳多糖对高脂血症小鼠SOD、GSH-Px、CAT基因mRNA表达的影响[J]. 江苏农业科学, 2017, 45(4): 124-127. DOI: 10.15889/j.issn.1002-1302.2017.04.039.
[108]李楠, 赵静, 吴茹, 等. 青钱柳多糖对高脂血症小鼠脂代谢及PPARγ、ATGL基因mRNA表达的影响[J]. 中国食品学报, 2015, 15(9): 9-14. DOI: 10.16429/j.1009-7848.2015.09.002.
[109]胡文兵, 赵静, 陈婷婷, 等. 青钱柳多糖对高脂血症小鼠的降血脂作用及机制初探[J]. 现代食品科技, 2015, 31(11): 39-44. DOI: 10.13982/j.mfst.1673-9078.2015.11.007.
[110]李燕, 蔡儒安, 潘如梨, 等. 青钱柳水提物降血糖及抗发炎功效研究[J]. 中国食品学报, 2021, 21(9): 102-109. DOI: 10.16429/j.1009-7848.2021.09.011.
[111]王蕾蕾, 高学敏. 贾岚, 等. 青钱柳对阴虚型2型糖尿病大鼠内分泌-免疫-环核苷酸系统的影响[J]. 中华中医药杂志, 2021, 36(2): 736-740.
[112]罗丹, 陈丹, 白曦晨, 等. 富硒青钱柳-蛹虫草复方小鼠免疫调节及抗氧化实验研究[J]. 食品与发酵科技, 2021, 57(4): 8-13,50. DOI: 10.3969/j.issn.1674-506X.2021.04.002.
[113]YU Y, MO S R, SHEN M Y, et al. Sulfated modification enhances the immunomodulatory effect of Cyclocarya paliurus polysaccharide on cyclophosphamide-induced immunosuppressed mice through MyD88-dependent MAPK/NF-κB and PI3K-Akt signaling pathways[J]. Food Research International, 2021, 150(Part A): 110756. DOI: 10.1016/j.foodres.2021.110756.
[114]ZHOU M M, QUEK S Y, SHANG X L, et al. Geographical variations of triterpenoid contents in Cyclocarya paliurus leaves and their inhibitory effects on HeLa cells[J]. Industrial Crops and Products, 2021, 162: 113314. DOI:10.1016/j.indcrop.2021.113314.
[115]XIE L M, HUANG Z B, QIN L, et al. Effects of sulfation and carboxymethylation on Cyclocarya paliurus polysaccharides: physicochemical properties, antitumor activities and protection against cellular oxidative stress[J]. International Journal of Biological Macromolecules, 2022, 204: 103-115. DOI:10.1016/j.ijbiomac.2022.01.192.
[116]DU X L, GUO K, MA Y Q, et al. Cyclocarya paliurus polysaccharide inhibits glioma cell U251 proliferation, migration, and invasion and promotes apoptosis via the GSK3β/β-catenin signaling pathway[J]. International Journal of Polymer Science, 2020, 2020: 2391439. DOI:10.1155/2020/2391439.
[117]HE Z W, LV F F, GAN Y L, et al. Anticancer effects of Cyclocarya paliurus polysaccharide (CPP) on thyroid carcinoma in vitro and in vivo[J]. International Journal of Polymer Science, 2018, 2018:2768120. DOI:10.1155/2018/2768120.
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