Journal of Guangxi Normal University(Natural Science Edition) ›› 2012, Vol. 30 ›› Issue (1): 60-66.

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Synthesis and Bioactivities of Benzo[c]phenanthridine Derivatives

NIE Yue-kun1, PAN Cheng-xue1, DAI Zhi-kai2, SU Gui-fa1   

  1. 1.State Key Laboratory Cultivation Base for the Chemistry andMolecular Engineering of Medicinal Resources,College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.Pharmacological Experiment Center,Guilin Medical College,Guilin Guangxi541004,China
  • Received:2011-10-28 Online:2012-01-20 Published:2018-12-03

Abstract: 11,12-Dihydrobenzo[c]phennanthridine derivatives were synthesized starting from aromatic aldehydes and o-methyl benzonitrilein an “one-pot” manner under a strong basic condition.The resulting productscould be further transformed to the benzo[c]phennanthridine-imidazol hybrid by reaction with methyl 3-aryl-3-cholo-2-oxo-propanate,or to benzo[c]phennanthridine derivatives by dehydrogenation to obtain eight target compounds.Their abilities to inhibit the cancer cell lines in vitro and ability tointeract with DNA were studied.The results of the study on bioactivities indicated that some of the compounds had obvious inhibition of certain cell lines andthe ability to interact with DNA.

Key words: benzo[c]phenanthridine derivatives, anti-tumor, DNA, imidazole

CLC Number: 

  • O629.72
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