Journal of Guangxi Normal University(Natural Science Edition) ›› 2011, Vol. 29 ›› Issue (3): 37-42.

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Synthesis and Crystal Structure of Conformationally ConstrainedDipeptide with 1-Aminocyclopropanecarboxylic Acid Residue

ZHANG Liu-sheng1,2, PAN Cheng-xue1,2, LI Li1,2, SU Gui-fa1,2, HUANG Wan-yun3, QIN Jiang-ke1,2, TANG Huang1,2   

  1. 1.State Key Laboratory Cultivation Base for the Chemistry andMolecular Engineering of Medicinal Resources,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    3.Department of Chemistry and Chemical Engineering,Guilin Normal College,Guilin Guangxi 541001,China
  • Received:2011-07-08 Online:2011-08-20 Published:2018-12-03

Abstract: Two conformationally constrained dipeptides with a trans-2,3-diaryl-1-aminocyclo-propanecarboxylic acid residue were synthesized from boc-(L)-phenylalanine,boc-(L)-alanine and 2,3-diphenyl-1-tert-butyl-cyclopropane carboxylic acid amide with the mixed anhydride methodology.The structures of two target compounds were studied by means of X-ray single crystal diffraction analysis.

Key words: conformationally constrained dipeptide, mixed anhydride methodology, synthesis, crystal structure

CLC Number: 

  • O629.72
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