限制钾离子电流抑制心脏中螺旋波和时空混沌

Suppressing Spiral Waves and Spatiotemporal Chaos in Cardiac Model by Restricting the Potassium Current

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Abstract: The potassium current has an important impact on theprocess of repolarization of myocardial cells.Suppression of spiral waves and spatiotemporal chaos in LuoRudy91 model is considered.The control strategy of restricting the potassium current is applied.Two numerical results are obtained.One is that the spiral wave and spatiotemporal chaos can be effectively suppressed by limiting the total current of potassium.The other is that the suppression of spiral wave and spatiotemporal chaos becomes difficult if one of the time-dependent and time-independent potassium current is not restrained.The control mechanism limiting the total potassium current can significantly prolong the effective refractory period of myocardial cells,lead to the result that spiral waves and spatiotemporal chaos can not be maintained,and thus,they are annihilated.

Key words: spiral wave, spatiotemporal chaos, potassium current

CLC Number:

O415.5

ZHONG Min, TANG Guo-ning. Suppressing Spiral Waves and Spatiotemporal Chaos in Cardiac Model by Restricting the Potassium Current[J].Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(2): 5-8.

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