限制钾离子电流抑制心脏中螺旋波和时空混沌

Abstract

Abstract: The potassium current has an important impact on theprocess of repolarization of myocardial cells.Suppression of spiral waves and spatiotemporal chaos in LuoRudy91 model is considered.The control strategy of restricting the potassium current is applied.Two numerical results are obtained.One is that the spiral wave and spatiotemporal chaos can be effectively suppressed by limiting the total current of potassium.The other is that the suppression of spiral wave and spatiotemporal chaos becomes difficult if one of the time-dependent and time-independent potassium current is not restrained.The control mechanism limiting the total potassium current can significantly prolong the effective refractory period of myocardial cells,lead to the result that spiral waves and spatiotemporal chaos can not be maintained,and thus,they are annihilated.

Key words: spiral wave, spatiotemporal chaos, potassium current

CLC Number:

O415.5

ZHONG Min, TANG Guo-ning. Suppressing Spiral Waves and Spatiotemporal Chaos in Cardiac Model by Restricting the Potassium Current[J].Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(2): 5-8.

References

[1] RODEN D M.Taking the “idio” out of “idiosyncratic”:predictingtorsadesde pointes[J].Pacing Clin Electrophysiol,1998,21:1029-1034.
[2] GARFINKEL A,KIM Y H,VOROSHILOVSKY O,et al.Preventing ventricular fibrillation by flattening cardiac restitution[J].PANS,2000,97:6061-6066.
[3] QU Zhi-lin,WEISS J N.Effects of Na⁺ and K⁺ channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissue[J].Am J Physiol Heart Circ Physiol,2005,289:1692-1701.
[4] QU Zhi-lin,WEISS J N,GARFINKEL A.Cardiac electrical restitution properties and stability of reentrant spiral waves:a simulation study[J].Am J Physiol Heart Circ Physiol,1999,276:269-283.
[5] 马军,应和平,李延龙,等.混沌信号驱动实现螺旋波和时空混沌控制[J].郑州大学学报:理学版,2006,38(1):45-49.
[6] 郝加波,周平.基于反馈系统和响应系统的混沌同步[J].四川师范大学学报:自然科学版,2005,28(5):611-614.
[7] 王玉芳,杨峰.一个非自治混沌电路的同步实现及其保密通信应用[J].山东师范大学学报:自然科学版,2007,22(1):25-28.
[8] 刘志勇,刘维清,夏英英,等.分子器件电路中的混沌效应[J].江西师范大学学报:自然科学版,2009,32(2):138-140.
[9] 曾维忠,夏国瑾,姚伟星,等.苄基四氢巴马汀对心肌动作电位及浦氏纤维跨膜钾、钙离子流的影响[J].中国药理学通报,1990,11:314-317.
[10] LUO C,RUDY Y.A model of the ventricular cardiac action potential:depolarization,repolarization,and their interaction[J].Circ Res,1991,68:1501-1526.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	CHEN Yong-qi, BAI Ke-zhao, KUANG hua, KONG Ling-jiang, LIU Mu-ren. Effect of Internal Layout on the Pedestrian Evacuation in the Classroom[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(1): 1 -4 .
[2]	XU Lun-hui, YE Fan. Acceleration Noise Model Based on Horizontal,Vertical and LateralAcceleration[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(1): 5 -9 .
[3]	YANG Li, KONG Ling-jiang. Capillary Force between Microparticles[J]. Journal of Guangxi Normal University(Natural Science Edition), 2012, 30(1): 1 -4 .
[4]	HE Qing, LIU Jian, WEI Lianfu. Single-Photon Detectors as the Physical Limit Detections of Weak Electromagnetic Signals[J]. Journal of Guangxi Normal University(Natural Science Edition), 2022, 40(5): 1 -23 .
[5]	BAI Ke-zhao, LUO Xu-dong, KONG Ling-jiang, LIU Mu-ren. Cellular Automaton Model of Date Transmission with Open Boundary Condition[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 1 -4 .
[6]	XU Lun-hui, LIAO Ran-kun. Signal Phasing-Sequence Optimization of Intersection Based on Traffic Track[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 5 -9 .
[7]	WANG Xiu-xin, QIN Li-mei, NONG Jing-hui, LIANG Zong-jin, ZHU Qi-jiang. Land Surface Temperature Retrieval with Mono-window Algorithm in Karst City[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 10 -14 .
[8]	LI Yu-fang, ZHANG Jun-jian. Strong Consistency of the Regression Weighted Function Estimator for Negatively Associated Samples[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 15 -19 .
[9]	JIA Bao-hua. A Strictly Stationary Associated Random Sequence Which Unsatisfythe Central Limit Theorem[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 20 -23 .
[10]	CHEN Cui-ling, LI Ming, LIANG Jia-mei, LI Lüe. A Class of New Conjugate Gradient Method and Its Convergence Property Under the Wolfe Line Search[J]. Journal of Guangxi Normal University(Natural Science Edition), 2010, 28(3): 24 -28 .

Suppressing Spiral Waves and Spatiotemporal Chaos in Cardiac Model by Restricting the Potassium Current

Abstract

Cite this article

share this article

References

Related Articles 3

Metrics

Comments

Recommended 10

[1]	ZHANG Xueliang,TAN Huili, BAI Kezhao, TANG Guoning,DENG Minyi. A Cellular Automaton Model Connected to the ConductionRestitution Property of Cardiac Cells [J]. Journal of Guangxi Normal University(Natural Science Edition), 2017, 35(4): 1-9.
[2]	HUANG Wen,TAN Huili. Effect of Cardiac Memory on Spiral Wave [J]. Journal of Guangxi Normal University(Natural Science Edition), 2017, 35(2): 1-8.
[3]	DAI Jingyu, ZHANG Xueliang, DENG Minyi, TAN Huili. Effect of Position Perturbation for Spiral Waves in Excitable Media [J]. Journal of Guangxi Normal University(Natural Science Edition), 2016, 34(2): 8-14.