广西师范大学学报（自然科学版） ›› 2024, Vol. 42 ›› Issue (3): 86-98.doi: 10.16088/j.issn.1001-6600.2023062102

• 研究论文 • 上一篇    下一篇

基于元胞自动机的Brugada综合征患者心电信号研究

李成乾, 石晨, 邓敏艺*   

  1. 广西师范大学 物理科学与技术学院, 广西 桂林 541004
  • 收稿日期:2023-06-21 修回日期:2023-10-26 发布日期:2024-05-31
  • 通讯作者: 邓敏艺(1973—), 女, 广西平南人, 广西师范大学教授。E-mail: dengminyi@gxnu.edu.cn
  • 基金资助:
    国家自然科学基金(12047567)

Study for the Electrocardiographic Signal of Brugada Syndrome Patients Using Cellular Automaton

LI Chengqian, SHI Chen, DENG Minyi*   

  1. College of Physical Science and Technology, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2023-06-21 Revised:2023-10-26 Published:2024-05-31

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摘要： 针对Brugada综合征(Brugada syndrome, BrS)患者的症状发展与其异常CV(conduction velocity, CV)恢复和异常APD(action potential duration, APD)恢复之间的联系仍未明确问题,本文采用元胞自动机模型对其进行研究。首先根据BrS患者心电信号的特点对元胞自动机模型进行量纲化处理,并在模型中考虑CV恢复和APD恢复;然后使用该模型数值模拟不同CV恢复及APD恢复下与心动过速对应的心电信号螺旋波态的演化行为。结果表明:只存在CV恢复时,心动过速只会维持,不会恶化;在CV恢复和无记忆APD恢复共同影响下,心动过速可能消失,也可能转化为心室颤动,其中转化为心室颤动的概率为54%,明显高于临床数据;在CV恢复和带记忆APD恢复共同影响下,心动过速可能消失、维持或转化为心室颤动,其中转化为心室颤动的概率约为35%,与临床数据一致。跟踪观察波头附近的心电信号传导情况,发现BrS患者的症状发展与CV恢复或APD恢复导致的电信号传导阻滞有关,传导阻滞的程度越严重,BrS患者就越容易由心动过速发展为心室颤动。记忆性APD恢复因其记忆效应能降低APD的振荡幅度,所以能降低心室颤动的发生率。

关键词: Brugada综合征, 心电信号, 元胞自动机, 心动过速, 心室颤动

Abstract: The relationship between the symptoms of Brugada Syndrome (BrS) patients and their abnormal conduction velocity (CV) restitution and abnormal action potential duration (APD) restitution are investigated using cellular automaton in this paper. Firstly, based on the characteristics of the electrocardiogram signals of BrS patients, the cellular automaton model is dimensionalized, and CV recovery and APD recovery are considered in the model. The behavior of the spiral wave of electrocardiographic signal related to the tachycardia is studied by using this model. The results indicate that only when CV recovery occurs, tachycardia will be maintained and will not worsen; Under the combined influence of CV recovery and memoryless APD recovery, tachycardia may disappear or transform into ventricular fibrillation, with a probability of 54%, significantly higher than clinical data; Under the combined influence of CV recovery and memory based APD recovery, tachycardia may disappear, maintain, or transform into ventricular fibrillation, with a conversion rate of 35% to ventricular fibrillation, which is consistent with clinical data. Tracking and observing the conduction of electrocardiogram signals near the wave head, it is found that the development of symptoms in BrS patients is related to the electrical signal conduction block caused by CV or APD recovery. The more severe the conduction block, the more likely BrS patients are to develop from tachycardia to ventricular fibrillation. Memory based APD recovery can reduce the incidence of ventricular fibrillation due to its memory effect, which can reduce the oscillation amplitude of APD.

Key words: Brugada syndrome, electrocardiographic signal, cellular automaton, tachycardia, ventricular fibrillation

中图分类号:  TN911.7;R541.7

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