广西师范大学学报（自然科学版） ›› 2012, Vol. 30 ›› Issue (2): 71-77.

• • 上一篇    下一篇

茚酮化合物的合成研究

潘成学1, 蒋祥柳2, 张洪彬2   

  1. 1.广西师范大学化学化工学院,药用资源化学与药物分子工程国家重点实验室培育基地,广西桂林541004;
    2.云南大学化学科学与工程学院,教育部自然资源药物化学重点实验室,云南昆明650091
  • 收稿日期:2011-12-03 出版日期:2012-06-20 发布日期:2018-12-03
  • 通讯作者: 张洪彬(1963—),男,云南文山人,云南大学教授,博导。E-mail:zhanghb@ynu.edu.cn
  • 基金资助:
    国家973重大基础研究计划子项目(2009CB522300)

Synthesis of Indanones Derivatives

PAN Cheng-xue1, JIANG Xiang-liu2, ZHANG Hong-bin2   

  1. 1.State Key Laboratory Cultivation Base for the Chemistry andMolecular Engineering of Medicinal Resources, College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,College of Chemistry and Chemical Engineering,Yunnan University,Kunming Yunnan 650091,China
  • Received:2011-12-03 Online:2012-06-20 Published:2018-12-03

摘要： 以芳香醛或邻苯二甲醚为原料,以分子内Friedel-Crafts酰基化、Nazarov环化、Pinacol重排等反应为主要合成策略,发展3条茚酮化合物的合成方法,共合成出8个茚酮化合物,所有产物的结构均经1H NMR、13C NMR表征和确认。合成方法具有原料价格低廉、实验操作简单、产率高等优点。

关键词: 茚酮化合物, Nazarov环化, Pinacol重排, 合成

Abstract: Eight indanones derivatives were synthesized by threeprocedures for preparation of indanone derivatives starting from aromatic aldehydes or 1,2-dimethoxy-benzene with the Friedel-Crafts acylation,Nazarov cyclization or Pinacol rearrangement as the key stepsin the synthesis,and the productswere characterized and confirmed by 1H NMR and 13C NMR.The protocols possess the advantages of cheap material,simple operation and high yields.

Key words: indanone derivatives, Nazarov cyclization, Pinacol rearrangement, synthesis

中图分类号: 

  • O625
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