广西师范大学学报（自然科学版） ›› 2024, Vol. 42 ›› Issue (1): 18-27.doi: 10.16088/j.issn.1001-6600.2023042408

• 综述 • 上一篇    下一篇

苦味受体的非味觉功能研究进展

王辉1,2, 冯平1,2*   

  1. 1.珍稀濒危动植物生态与环境保护教育部重点实验室(广西师范大学),广西 桂林 541006;
    2.广西师范大学 生命科学学院,广西 桂林 541006
  • 收稿日期:2023-04-24 修回日期:2023-05-20 出版日期:2024-01-25 发布日期:2024-01-19
  • 通讯作者: 冯平(1986—),女,广西北海人,广西师范大学副教授,博士。E-mail: fengfengping1234@163.com
  • 基金资助:
    国家自然科学基金(32060111);珍稀濒危动植物生态与环境保护教育部重点实验室研究基金(ERESEP2022Z02);广西师范大学研究生优秀学位论文培育计划项目(2022EMT025)

Advanced Researches on Bitter Taste Receptors in Extra-oral Function

WANG Hui1,2, FENG Ping1,2*   

  1. 1. Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin Guangxi 541006, China;
    2. College of Life Sciences, Guangxi Normal University, Guilin Guangxi 541006, China
  • Received:2023-04-24 Revised:2023-05-20 Online:2024-01-25 Published:2024-01-19

PDF (PC)

370

摘要： 苦味的识别对动物生存至关重要,该过程由苦味受体介导。食物中的化学物质刺激口腔内的苦味感受器,经信号传导反馈给大脑,产生苦味感知并最终影响食物的选择和排斥。除了基本的味觉功能,苦味受体在口腔外的其他器官和组织中普遍表达,在细胞增殖、代谢调控、免疫反应等重要的生理生化过程中发挥作用。尽管苦味受体的蛋白结构仍未得到全部解析,具体的功能和作用机制未知,但由于其亚型众多且分布广泛,是理想的靶点,并将成为各类疾病治疗的重要探究方向。本文介绍苦味受体在口腔外部分器官组织中的表达和在相关疾病中的研究进展,有助于全面系统理解苦味受体的重要作用。

关键词: 苦味受体, 味觉功能, 苦味激动剂, 代谢调控

Abstract: Bitter taste detection is essential for animal survival. Bitter taste receptors are encoded by bitter taste receptor genes. Bitter chemicals in food stimulate bitter taste receptors in the oral cavity. The information is fed back to the brain via signal conduction to mediate bitter taste perception and ultimately influence food selection and rejection. In exception to the basic taste perception functions, bitter taste receptors are commonly expressed in other organs and tissues beyond the oral cavity playing important roles in cell reproduction, metabolic regulation, inflammation and other important biochemical responses. Although the experimental structures of bitter taste receptors are lacking, it is still important on the treatment of diseases as ideal drug targets due to numerous subtypes and broad expressions. This review presents the expressions of bitter taste receptors in some tissues outside the oral cavity and research advances in diseases, which can help to understand bitter taste receptors comprehensively.

Key words: bitter taste receptors, gustatory function, bitter agonists, metabolic regulation

中图分类号:  Q-1

[1] BEHRENS M, MEYERHOF W. Vertebrate bitter taste receptors: keys for survival in changing environments[J]. Journal of Agricultural and Food Chemistry, 2018, 66(10): 2204-2213. DOI: 10.1021/acs.jafc.6b04835.
[2] ZHONG H M, HUANG J, SHANG S, et al. Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians[J]. Ecology and Evolution, 2021, 11(24): 18011-18025.DOI: 10.1002/ece3.8398.
[3] WANG K, ZHAO H B. Birds generally carry a small repertoire of bitter taste receptor genes[J]. Genome Biology and Evolution, 2015, 7(9): 2705-2715.DOI: 10.1093/gbe/evv180.
[4] ZHONG H M, SHANG S, WU X Y, et al. Genomic evidence of bitter taste in snakes and phylogenetic analysis of bitter taste receptor genes in reptiles[J]. PeerJ, 2017, 5: e3708.DOI: 10.7717/peerj.3708.
[5] BEHRENS M, ZIEGLER F. Structure-function analyses of human bitter taste receptors-where do we stand?[J]. Molecules, 2020, 25(19): 4423.DOI: 10.3390/molecules25194423.
[6] LIU Z J, LIU G J, HAILER F, et al. Dietary specialization drives multiple independent losses and gains in the bitter taste gene repertoire of Laurasiatherian Mammals[J]. Frontiers in Zoology, 2016, 13: 28.DOI: 10.1186/s12983-016-0161-1.
[7] SHANG S, ZHANG H X, WU X Y, et al. The repertoire of bitter taste receptor genes in Ovalentaria fish[J]. Environmental Biology of Fishes, 2017, 100(11): 1489-1496.DOI: 10.1007/s10641-017-0659-1.
[8] WOODING S P, RAMIREZ V A, BEHRENS M. Bitter taste receptors: genes, evolution and health[J]. Evolution, Medicine, and Public Health, 2021, 9(1): 431-447.DOI: 10.1093/emph/eoab031.
[9] MEYERHOF W, BATRAM C, KUHN C, et al. The molecular receptive ranges of human TAS2R bitter taste receptors[J]. Chemical Senses, 2010, 35(2): 157-170.DOI: 10.1093/chemse/bjp092.
[10] HAYAKAWA T, SUZUKI-HASHIDO N, MATSUI A, et al. Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade[J]. Molecular Biology and Evolution, 2014, 31(8): 2018-2031.DOI: 10.1093/molbev/msu144.
[11] TÖLE J C, BEHRENS M, MEYERHOF W. Taste receptor function[J]. Handbook of Clinical Neurology, 2019, 164: 173-185.DOI: 10.1016/B978-0-444-63855-7.00011-3.
[12] BEHRENS M, LANG T. Extra-oral taste receptors-function, disease, and perspectives[J]. Frontiers in Nutrition, 2022, 9: 881177.DOI: 10.3389/fnut.2022.881177.
[13] KANG W, WANG Y W, LI J Y, et al. TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment[J]. Stem Cell Research & Therapy, 2022, 13(1): 374.DOI: 10.1186/s13287-022-03057-x.
[14] GRASSIN-DELYLE S, SALVATOR H, MANTOV N, et al. Bitter Taste receptors (TAS2Rs) in human lung macrophages: receptor expression and inhibitory effects of TAS2R agonists[J]. Frontiers in Physiology, 2019, 10: 1267.DOI: 10.3389/fphys.2019.01267.
[15] SINGH N, VRONTAKIS M, PARKINSON F, et al. Functional bitter taste receptors are expressed in brain cells[J]. Biochemical and Biophysical Research Communications, 2011, 406(1): 146-151.DOI: 10.1016/j.bbrc.2011.02.016.
[16] CHENG W, YAO M Y, LIU F N. Bitter taste receptor as a therapeutic target in orthopaedic disorders[J]. Drug Design, Development and Therapy, 2021, 15: 895-903.DOI: 10.2147/DDDT.S289614.
[17] LIU W J, GONG T, SHI F X, et al. Taste receptors affect male reproduction by influencing steroid synthesis[J]. Frontiers in Cell and Developmental Biology, 2022, 10: 956981.DOI: 10.3389/fcell.2022.956981.
[18] BLOXHAM C J, FOSTER S R, THOMAS W G. A Bitter taste in your heart[J]. Frontiers in Physiology, 2020, 11: 431.DOI: 10.3389/fphys.2020.00431.
[19] AVAU B, DEPOORTERE I. The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity[J]. Acta Physiologica, 2016, 216(4): 407-420.DOI: 10.1111/apha.12621.
[20] LI F, ZHOU M L. Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice[J]. Molecular Human Reproduction, 2012, 18(6): 289-297.DOI: 10.1093/molehr/gas005.
[21] WELCOME M O. The bitterness of genitourinary infections: Properties, ligands of genitourinary bitter taste receptors and mechanisms linking taste sensing to inflammatory processes in the genitourinary tract[J]. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2020, 247: 101-110.DOI: 10.1016/j.ejogrb.2020.02.015.
[22] HO H K Y, BIGLIARDI P L, STELMASHENKO O, et al. Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor[J]. Experimental Dermatology, 2021, 30(2): 216-225.DOI: 10.1111/exd.14250.
[23] WELCOME M O, DOGO D, MASTORAKIS N E. Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases[J]. Inflammopharmacology, 2023, 31(1): 89-117.DOI: 10.1007/s10787-022-01086-9.
[24] MALKI A, FIEDLER J, FRICKE K, et al. Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes[J]. Journal of Leukocyte Biology, 2015, 97(3): 533-545.DOI: 10.1189/jlb.2A0714-331RR.
[25] KOK B P, GALMOZZI A, LITTLEJOHN N K, et al. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits[J]. Molecular Metabolism, 2018, 16: 76-87.DOI: 10.1016/j.molmet.2018.07.013.
[26] LUO X C, CHEN Z H, XUE J B, et al. Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells[J]. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(12): 5564-5569.DOI: 10.1073/pnas.1812901116.
[27] PRANDI S, VOIGT A, MEYERHOF W, et al. Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells[J]. Cellular and Molecular Life Sciences, 2018, 75(1): 49-65.DOI: 10.1007/s00018-017-2621-y.
[28] YAMAZAKI T, TAKAHASHI C, TANIGUCHI Y, et al. Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells[J]. Biochemical and Biophysical Research Communications, 2020, 533(4): 704-709.DOI: 10.1016/j.bbrc.2020.10.099.
[29] WIDMAYER P, PARTSCH V, POSPIECH J, et al. Distinct cell types with the bitter receptor Tas2r126 in different compartments of the stomach[J]. Frontiers in Physiology, 2020, 11: 32.DOI: 10.3389/fphys.2020.00032.
[30] LISZT K I, LEY J P, LIEDER B, et al. Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(30): E6260-E6269.DOI: 10.1073/pnas.1703728114.
[31] CAREY R M, LEE R J. Taste receptors in upper airway innate immunity[J]. Nutrients, 2019, 11(9): 2017.DOI: 10.3390/nu11092017.
[32] YAN C H, HAHN S, MCMAHON D, et al. Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity[J].American Journal of Rhinology & Allergy, 2017, 31(2): 85-92.DOI: 10.2500/ajra.2017.31.4424.
[33] CAREY R M, WORKMAN A D, YAN C H, et al. Sinonasal T2R-mediated nitric oxide production in response to Bacillus cereus[J]. American Journal of Rhinology & Allergy, 2017, 31(4): 211-215.DOI: 10.2500/ajra.2017.31.4453.
[34] SAUNDERS C J, CHRISTENSEN M, FINGER T E, et al. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(16): 6075-6080.DOI: 10.1073/pnas.1402251111.
[35] BARHAM H P, COOPER S E, ANDERSON C B, et al. Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa[J]. International Forum of Allergy & Rhinology, 2013, 3(6): 450-457.DOI: 10.1002/alr.21149.
[36] TUZIM K, KOROLCZUK A. An update on extra-oral bitter taste receptors[J].Journal of Translational Medicine, 2021, 19(1): 440.DOI: 10.1186/s12967-021-03067-y.
[37] LUND T C, KOBS A J, KRAMER A, et al. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression[J]. PLoS One, 2013, 8(3): e58945.DOI: 10.1371/journal.pone.0058945.
[38] TRAN H T T, HERZ C, RUF P, et al. Human T2R38 bitter taste receptor expression in resting and activated lymphocytes[J]. Frontiers in Immunology, 2018, 9: 2949.DOI: 10.3389/fimmu.2018.02949.
[39] MAURER S, WABNITZ G H, KAHLE N A, et al. Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone[J]. Frontiers in Immunology, 2015, 6: 369.DOI: 10.3389/fimmu.2015.00369.
[40] SOULTANOVA A, VOIGT A, CHUBANOV V, et al. Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131[J]. International Immunopharmacology, 2015, 29(1): 143-147.DOI: 10.1016/j.intimp.2015.06.005.
[41] TAHER S, BORJA Y, CABANELA L, et al. Cholecystokinin, gastrin, cholecystokinin/gastrin receptors, and bitter taste receptor TAS2R14: trophoblast expression and signaling[J]. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 2019, 316(5): R628-R639.DOI: 10.1152/ajpregu.00153.2018.
[42] WÖLFLE U, ELSHOLZ F A, KERSTEN A, et al. Expression and functional activity of the human bitter taste receptor TAS2R38 in human placental tissues and JEG-3 cells[J]. Molecules, 2016, 21(3): 306.DOI: 10.3390/molecules21030306.
[43] LOSSOW K, HÜBNER S, ROUDNITZKY N, et al. Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans[J]. The Journal of Biological Chemistry, 2016, 291(29): 15358-15377.DOI: 10.1074/jbc.M116.718544.
[44] ZHENG K Z, LU P, DELPAPA E, et al. Bitter taste receptors as targets for tocolytics in preterm labor therapy[J]. FASEB Journal, 2017, 31(9): 4037-4052.DOI: 10.1096/fj.201601323RR.
[45] ALI M A, WANG Y H, QIN Z Y, et al. Odorant and taste receptors in sperm chemotaxis and cryopreservation: roles and implications in sperm capacitation, motility and fertility[J]. Genes, 2021, 12(4): 488.DOI: 10.3390/genes12040488.
[46] GOVERNINI L, SEMPLICI B, PAVONE V, et al. Expression of taste receptor 2 subtypes in human testis and sperm[J]. Journal of Clinical Medicine, 2020, 9(1): 264.DOI: 10.3390/jcm9010264.
[47] DUARTE A C, SANTOS J, COSTA A R, et al. Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier[J]. Biochemical Pharmacology, 2020, 177: 113954.DOI: 10.1016/j.bcp.2020.113954.
[48] ANSOLEAGA B, GARCIA-ESPARCIA P, PINACHO R, et al. Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia[J]. Journal of Psychiatric Research, 2015, 60: 109-116.DOI: 10.1016/j.jpsychires.2014.09.012.
[49] DUARTE A C, COSTA A R, GONÇALVES I, et al. The druggability of bitter taste receptors for the treatment of neurodegenerative disorders[J]. Biochemical Pharmacology, 2022, 197: 114915.DOI: 10.1016/j.bcp.2022.114915.
[50] 付琳, 付强, 李冀, 等. 黄连化学成分及药理作用研究进展[J].中医药学报, 2021, 49(2): 87-92.DOI: 10.19664/j.cnki.1002-2392.210044.
[51] 苏佳昇, 李晓霞, 蒋雅娴, 等. 苦参化学成分与药理作用研究进展[J]. 湖北农业科学, 2021, 60(1): 5-9.DOI: 10.14088/j.cnki.issn0439-8114.2021.01.001.
[52] 周新新, 崔悦, 朱鹤云, 等. 栀子的化学成分、药理作用及提取工艺的研究进展[J]. 吉林医药学院学报, 2021, 42(5): 374-376.DOI: 10.13845/j.cnki.issn1673-2995.2021.05.021.
[53] 吕佳桦, 朱婵, 唐宗湘. 中药药性中“苦味”形成机制及生物学意义[J]. 广西师范大学学报(自然科学版), 2022, 40(5): 324-331.DOI: 10.16088/j.issn.1001-6600.2021100801.
[54] YUAN Y M, FANG X M, YE W D. Acrid and bitter Chinese herbs in decoction effectively relieve lung inflammation and regulation of TRPV1/TAS2R14 channels in a rat asthmatic model[J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022: 8061740.DOI: 10.1155/2022/8061740.
[55] MAINA I W, WORKMAN A D, COHEN N A. The role of bitter and sweet taste receptors in upper airway innate immunity: recent advances and future directions[J]. World Journal of Otorhinolaryngology - Head and Neck Surgery, 2018, 4(3): 200-208.DOI: 10.1016/j.wjorl.2018.07.003.
[56] HARIRI B M, McMAHON D B, CHEN B, et al. Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor[J]. Journal of Biological Chemistry, 2017, 292(20): 8484-8497.DOI: 10.1074/jbc.M116.771949.
[57] MARTENS K, STEELANT B, BULLENS D M A. Taste receptors: the gatekeepers of the airway epithelium[J]. Cells, 2021, 10(11): 2889.DOI: 10.3390/cells10112889.
[58] ZHOU Y W, SUN J, WANG Y, et al. Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling[J]. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(26): e2121513119.DOI: 10.1073/pnas.2121513119.
[59] WANG Y, WANG A L, ZHANG M, et al. Artesunate attenuates airway resistance in vivo and relaxes airway smooth muscle cells in vitro via bitter taste receptor-dependent calcium signalling[J]. Experimental Physiology, 2019, 104(2): 231-243.DOI: 10.1113/EP086824.
[60] CONAWAY S Jr, NAYAK A P, DESHPANDE D A. Therapeutic potential and challenges of bitter taste receptors on lung cells[J]. Current Opinion in Pharmacology, 2020, 51: 43-49.DOI: 10.1016/j.coph.2020.07.004.
[61] DU X Y, ZHI J, YANG D, et al. Research progress in the mechanism of calcium ion on contraction and relaxation of airway smooth muscle cells[J]. Journal of Receptor and Signal Transduction Research, 2021, 41(2): 117-122.DOI: 10.1080/10799893.2020.1806315.
[62] TALMON M, POLLASTRO F, FRESU L G. The complex journey of the calcium regulation downstream of TAS2R activation[J]. Cells, 2022, 11(22): 3638.DOI: 10.3390/cells11223638.
[63] NAYAK A P, VILLALBA D, DESHPANDE D A. Bitter taste receptors: an answer to comprehensive asthma control?[J]. Current Allergy and Asthma Reports, 2019, 19(10): 48.DOI: 10.1007/s11882-019-0876-0.
[64] 郭雪冬, 仪慧兰. 黄芩苷通过苦味受体促进哮喘小鼠呼吸道炎性细胞凋亡[J]. 中国生物化学与分子生物学报, 2022, 38(5): 680-688.DOI: 10.13865/j.cnki.cjbmb.2022.03.1538.
[65] GOPALLAWA I, FREUND J R, LEE R J. Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling[J]. Cellular and Molecular Life Sciences, 2021, 78(1): 271-286.DOI: 10.1007/s00018-020-03494-y.
[66] JERUZAL-ŚWIATECKA J, FENDLER W, PIETRUSZEWSKA W. Clinical role of extraoral bitter taste receptors[J].International Journal of Molecular Sciences, 2020, 21(14): 5156.DOI: 10.3390/ijms21145156.
[67] SINGH N, SHAIK F A, MYAL Y, et al. Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells[J]. Molecular and Cellular Biochemistry, 2020, 465(1/2): 199-214.DOI: 10.1007/s11010-019-03679-5.
[68] MARTIN L T P, NACHTIGAL M W, SELMAN T, et al. Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival[J]. Molecular and Cellular Biochemistry, 2019, 454(1/2): 203-214.DOI: 10.1007/s11010-018-3464-z.
[69] STERN L, GIESE N, HACKERT T, et al. Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10[J]. Journal of Cancer, 2018, 9(4): 711-725.DOI: 10.7150/jca.21803.
[70] SEO Y, KIM Y S, LEE K E, et al. Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells[J]. PLoS One, 2017, 12(5): e0176851.DOI: 10.1371/journal.pone.0176851.
[71] SALVESTRINI V, CICIARELLO M, PENSATO V, et al. Denatonium as a bitter taste receptor agonist modifies transcriptomic profile and functions of acute myeloid leukemia cells[J]. Frontiers in Oncology, 2020, 10: 1225.DOI: 10.3389/fonc.2020.01225.
[72] ZEHENTNER S, REINER A T, GRIMM C, et al. The role of bitter taste receptors in cancer: a systematic review[J]. Cancers, 2021, 13(23): 5891.DOI: 10.3390/cancers13235891.
[73] GAIDA M M, MAYER C, DAPUNT U, et al. Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule[J]. Oncotarget, 2016, 7(11): 12623-12632.DOI: 10.18632/oncotarget.7206.
[74] CHOI J H, LEE J, CHOI I J, et al. Genetic variation in the TAS2R38 bitter taste receptor and gastric cancer risk in koreans[J]. Scientific Reports, 2016, 6: 26904.DOI: 10.1038/srep26904.
[75] CARRAI M, STEINKE V, VODICKA P, et al. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin[J]. PLoS One, 2011, 6(6): e20464.DOI: 10.1371/journal.pone.0020464.
[76] WÖLFLE U, HAARHAUS B, KERSTEN A, et al. Salicin from willow bark can modulate neurite outgrowth in human neuroblastoma SH-SY5Y cells[J]. Phytotherapy Research, 2015, 29(10): 1494-500.DOI: 10.1002/ptr.5400.
[77] CHOI J H, LEE J, YANG S, et al. Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females[J]. Scientific Reports, 2018, 8(1): 15004.DOI: 10.1038/s41598-018-33338-6.
[78] TSUTSUMI R, GODA M, FUJIMOTO C, et al. Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer[J]. The Laryngoscope, 2016, 126(3): E103-E109.DOI: 10.1002/lary.25679.
[79] XIE C, WANG X Y, YOUNG R L, et al. Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control[J].Frontiers in Endocrinology, 2018, 9: 576.DOI: 10.3389/fendo.2018.00576.
[80] GRAU-BOVÉ C, MIGUÉNS-GÓMEZ A, GONZÁLEZ-QUILEN C, et al. Modulation of food intake by differential TAS2R stimulation in rat[J]. Nutrients, 2020, 12(12): 3784.DOI: 10.3390/nu12123784.
[81] TURNER A, VEYSEY M, KEELY S, et al. Interactions between bitter taste, diet and dysbiosis: consequences for appetite and obesity[J]. Nutrients, 2018, 10(10): 1336.DOI: 10.3390/nu10101336.
[82] BECKETT E L, MARTIN C, YATES Z, et al. Bitter taste genetics-the relationship to tasting, liking, consumption and health[J]. Food & Function, 2014, 5(12): 3040-3054.DOI: 10.1039/c4fo00539b.
[83] LATORRE R, HUYNH J, MAZZONI M, et al. Expression of the bitter taste receptor, T2R38, in enteroendocrine cells of the colonic mucosa of overweight/obese vs. lean subjects[J]. PLoS One, 2016, 11(2): e0147468.DOI: 10.1371/journal.pone.0147468.
[84] LISZT K I, WANG Q L, FARHADIPOUR M, et al. Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity[J]. The Journal of Clinical Investigation, 2022, 132(3): e144828.DOI: 10.1172/JCI144828.
[85] WANG Q L, LISZT K I, DELOOSE E, et al. Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut[J]. FASEB Journal, 2019, 33(4): 4907-4920.DOI: 10.1096/fj.201801661RR.
[86] DOTSON C D, ZHANG L, XU H, et al. Bitter taste receptors influence glucose homeostasis[J]. PLoS One, 2008, 3(12): e3974.DOI: 10.1371/journal.pone.0003974.
[87] XU W X, WU L J, LIU S H, et al. Structural basis for strychnine activation of human bitter taste receptor TAS2R46[J]. Science, 2022, 377(6612): 1298-1304.DOI: 10.1126/science.abo1633.
[88] 王曼莉, 孙志广. 胃肠苦味受体与胃肠动力相关性的研究进展[J]. 陕西中医药大学学报, 2022, 45(2): 132-136.DOI: 10.13424/j.cnki.jsctcm.2022.02.029.
[1] 吕佳桦, 朱婵, 唐宗湘. 中药药性中“苦味”形成机制及生物学意义[J]. 广西师范大学学报（自然科学版）, 2022, 40(5): 324-331.
[2] 庞冰冰, 叶丰彩, 李钰艳, 尚常花. 微藻类胡萝卜素合成与代谢调控研究进展[J]. 广西师范大学学报（自然科学版）, 2021, 39(6): 13-23.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 罗云演, 李容正, 李冰, 丁晨旭. 响应面优化多刺绿绒蒿总生物碱提取工艺[J]. 广西师范大学学报（自然科学版）, 2014, 32(4): 84 -90 .
[2] 董淑龙, 马姜明, 辛文杰. 景观视觉评价研究进展与趋势——基于CiteSpace的知识图谱分析[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 1 -13 .
[3] 郭嘉梁, 靳婷. 基于语义增强的多模态情感分析[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 14 -25 .
[4] 吴正清, 曹晖, 刘宝锴. 基于注意力卷积神经网络的中文虚假评论检测[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 26 -36 .
[5] 梁正友, 蔡俊民, 孙宇, 陈磊. 结合残差动态图卷积与特征强化的点云分类[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 37 -48 .
[6] 欧阳舒歆, 王洺钧, 荣垂田, 孙华波. 基于改进LSTM的多维QAR数据异常检测[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 49 -60 .
[7] 李依洋, 曾才斌, 黄在堂. 分数Brown运动驱动的具有壁附着的恒化器模型的随机吸引子[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 61 -68 .
[8] 李鹏博, 李永祥. 外部区域上p-Laplace方程的径向对称解[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 69 -75 .
[9] 吴子弦, 成军, 符坚铃, 周心雯, 谢佳龙, 宁全. 基于PI的Semi-Markovian电力系统事件触发控制设计分析[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 76 -85 .
[10] 程蕾, 闫普选, 杜博豪, 叶思, 邹华红. MOF-2的水相合成及其热稳定和介电性能研究[J]. 广西师范大学学报（自然科学版）, 2023, 41(5): 86 -95 .
版权所有 © 广西师范大学学报（自然科学版）编辑部
地址：广西桂林市三里店育才路15号　邮编：541004
电话：0773-5857325　E-mail: gxsdzkb@mailbox.gxnu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发