广西师范大学学报（自然科学版） ›› 2022, Vol. 40 ›› Issue (5): 300-306.doi: 10.16088/j.issn.1001-6600.2022031008

• 综述 • 上一篇    下一篇

刺激响应型纳米酶及其原位催化增强肿瘤治疗

梁家玮1,2,3, 孙婉莹1,2,3, 罗刘睿麒1,2,3, 蒋邦平1,2,3, 沈星灿1,2,3*   

  1. 1.广西师范大学 化学与药学学院, 广西 桂林 541004;
    2.药用资源化学与药物分子工程教育部重点实验室(广西师范大学), 广西 桂林 541004;
    3.省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学), 广西 桂林 541004
  • 收稿日期:2022-03-10 修回日期:2022-04-20 出版日期:2022-09-25 发布日期:2022-10-18
  • 通讯作者: 沈星灿 (1974—), 女, 湖南邵阳人, 广西师范大学教授, 博导。E-mail: xcshen@gxnu.edu.cn
  • 基金资助:
    国家自然科学基金(21671046,21977022); 广西自然科学基金创新团队项目(2018GXNSFFA281004); 广西自然科学基金杰出青年基金(2013GXNSFGA019001)

Stimulus-Responsive Nanozymes and Their in Situ Catalytic Enhancement of Tumor Therapy

LIANG Jiawei1,2,3, SUN Wanying1,2,3, LUO-LIU Ruiqi1,2,3, JIANG Bangping1,2,3, SHEN Xingcan1,2,3*   

  1. 1. School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi, 541004, China;
    2. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China, Guilin Guangxi 541004, China;
    3. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University), Guilin Guangxi 541004, China
  • Received:2022-03-10 Revised:2022-04-20 Online:2022-09-25 Published:2022-10-18

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摘要： 纳米酶是一种具有类酶催化活性的纳米材料。本文综述刺激响应型纳米酶及其在肿瘤微环境中通过调节肿瘤微环境的酸度、升高过氧化氢的浓度、消除抗氧化分子等策略,促进纳米酶在肿瘤细胞内催化产生活性氧物种,提高化学动力学治疗肿瘤效果,并综述纳米酶在内源性刺激化学动力学治疗的基础上,协同外源性刺激的光动力治疗、光热治疗、声动力治疗、放射治疗以及联合免疫治疗,实现肿瘤高效精准治疗的研究进展。

关键词: 纳米酶, 级联催化反应, 刺激响应机制, 催化治疗, 肿瘤治疗, 免疫治疗

Abstract: Nanozyme is a kind of nanomaterial with enzyme-like catalytic activity. Tumor microenvironment has its own unique biochemical characteristics, and this review summarizes that stimulating responsive nanozyme in tumor microenvironment can promote ROS production to enhance chemodynamic therapy in situ, by regulating acidity, increasing H2O2 concentration, changing glucose metabolism, eliminating antioxidants. Based on this, the research progress of nanozyme catalytic therapy synergistic photodynamic therapy, photothermal therapy, sonodynamic therapy, radiotherapy and immunotherapy were further reviewed.

Key words: nanozyme, cascade catalytic reaction, stimulus response mechanism, catalytic treatment, tumor treatment, immunotherapy

中图分类号: 

  • TB383.1
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