Journal of Guangxi Normal University(Natural Science Edition) ›› 2014, Vol. 32 ›› Issue (2): 101-105.

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Synthesis of N-Methyl Moxifloxacin Hydrochloride and Its Application in Production

ZHENG Qing-si1,2, LIN Mei-fang2, TANG Huang1,3   

  1. 1.College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China;
    2. Guilin Pharmaceutical Co., Ltd., Guilin Guangxi 541002, China;
    3. State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2013-12-10 Online:2014-06-25 Published:2018-09-25

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Abstract: N-methyl moxifloxacin hydrochloride (1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS, 7aS)-N-methy-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride) was synthesized with quinoline carboxylic ethyl ester as starting materials via esterification protection, condensation with side chain and reaction with formaldehyde after deprotecting. The target compound was characterized by ESI-MS, 1H NMR and 13C NMR. The applying in production monitoring and quality standardof the compound was also studied.

Key words: N-methyl moxifloxacin hydrochloride, synthesis, quality standard, quinolone, antibiotics

CLC Number: 

  • O623.5
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