Journal of Guangxi Normal University(Natural Science Edition) ›› 2021, Vol. 39 ›› Issue (3): 131-138.doi: 10.16088/j.issn.1001-6600.2020121604

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Drug Metabolism and Evolution of CYP2D Subfamily Genes in Primates

DONG Xiaoyan1,2, LIANG Qiufang1,2, FENG Ping1,2*   

  1. 1. Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin Guangxi 541006, China;
    2. College of Life Sciences, Guangxi Normal University, Guilin Guangxi 541006, China
  • Received:2020-12-16 Revised:2021-01-30 Published:2021-05-13

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Abstract: CYP2D subfamily genes are commonly found in primates and play an important role in drug metabolism. However, the effect of CYP2D enzyme on the metabolism of the same drug varies in different regions and races, and the CYP2D enzyme in non-human primates metabolizes some drugs more efficiently than that in humans. In addition, during the long evolutionary process, primate CYP2D subfamily genes will experience frequent gene duplication or gene loss, leading to differences in the number of CYP2D subfamily genes, but it has not been determined whether such differences are related to the species’ genetic relationship. In this study, we reviewed the studies on drug metabolism and evolution of CYP2D subfamily genes in primates, in order to provide some theoretical basis for the realization of individualized medication and precise therapy, and further understand the evolution of CYP2D subfamily genes in primates.

Key words: CYP2D subfamily gene, primates, drug metabolism, polymorphism, evolution

CLC Number: 

  • R965
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