Journal of Guangxi Normal University(Natural Science Edition) ›› 2026, Vol. 44 ›› Issue (5): 16-26.doi: 10.16088/j.issn.1001-6600.2026012101

• Physical and Electronic Engineering • Previous Articles     Next Articles

Giant magnetoimpedance biosensor based on composite amorphous wire for sensitive detection of cTnI

Yang Zhen1,2,3,4*, Tang Yue1,2,3,4, Geng Zhaojie1,2,3,4, Yin Xu1,2,3,4, Huang Yong5   

  1. 1. Guangxi Key Laboratory of Brain-Inspired Computing and Intelligent Chips (Guangxi Normal University), Guilin Guangxi 541004, China;
    2. Guangxi Universities Key Laboratory of Integrated Circuits and Microsystems (Guangxi Normal University), Guilin Guangxi 541004, China;
    3. Guangxi Universities Engineering Research Center for Optoelectronic Information Technology (Guangxi Normal University), Guilin Guangxi 541004, China;
    4. School of Electronics and Information Engineering/School of Integrated Circuits, Guangxi Normal University, Guilin Guangxi 541004, China;
    5. Shanghai Yongtou Zhichuang Semiconductor Co., Ltd., Shanghai 201900, China
  • Received:2026-01-21 Revised:2026-03-11 Online:2026-09-05 Published:2026-07-24

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Abstract: In order to enhance the giant magnetoimpedance (GMI) performance and sensitivity of amorphous microwires, this study fabricates carbon nano-layer-coated Co-based composite amorphous microwires by using magnetron sputtering technology. The carbon layer thicknesses are set at 67, 203, 334, 467, and 601 nm, respectively. A systematic investigation is conducted on the microstructure, magnetic properties, and the influence of varying carbon layer thicknesses on the giant magnetoimpedance effect in the composite microwires. The results indicate that the composite amorphous wire with a carbon layer thickness of 334 nm exhibits optimal GMI performance, achieving a maximum GMI ratio of 522% and a corresponding sensitivity of 33.8% Oe-1. By constructing a GMI biosensing element from this high-performance composite amorphous wire and integrating it with a bio-molecular reaction interface based on a patterned SiO2 thin film and a PDMS microfluidic chip, ultrasensitive detection of cardiac troponin I(cTnI) is accomplished via a sandwich immunoassay. Experimental results demonstrate that the sensor exhibits a favorable linear response within the concentration range of 0.001-500 μg/L, with a detection limit as low as 0.001 μg/L, along with outstanding specificity, stability, and anti-interference capability. This study provides significant support for biomolecular detection technology based on the GMI effect in amorphous wires.

Key words: composite amorphous wire, giant magnetoimpedacne effect, biosensor, cardinac troponin I(cTnI), biological detection

CLC Number:  TB33;TP212.3
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