Journal of Guangxi Normal University(Natural Science Edition) ›› 2023, Vol. 41 ›› Issue (6): 150-157.doi: 10.16088/j.issn.1001-6600.2023041802

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Secondary Metabolites and Its Hypoglycemic of Endophytic Fungus Penicillium sp. GXIMD00006 Derived from the Bruguiera gymnorrhiza

XIAO Ze'en1,2, ZOU Sihua1,2, JIANG Jiao1,2, LUO Haimei1,2, HUANG Xishan3, LIU Yonghong1,2, TAN Zhen1,2*   

  1. 1. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China;
    2. Guangxi Key Laboratory of Marine Drugs (Guangxi University of Chinese Medicine), Nanning Guangxi 530200, China;
    3. School of Chemistry and Pharmacy, Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2023-04-18 Revised:2023-05-12 Published:2023-12-04

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Abstract: In order to explore the hypoglycemic effect of endophytic fungi from the mangrove Bruguiera gymnorrhiza, the endophytic fungus Penicillium sp. GXIMD00006 was fermented and isolated by various column chromatography techniques. By using MS, NMR and literature comparison,11 compounds were identified as (+)-sclerotiorin (1), sclerotioramine (2), isochromophilone VIII (3), terretonin (4), terretonin A (5), chrodrimanin A (6), chrodrimanin B (7), chrodrimanin E (8), (22E,24R)-3β,5α-dihydroxy-ergosta-7, 22-dien-6-one (9), erogosterol (10) and ergosterol peroxide (11). Besides, terretonin (4) and terretonin A (5) were first isolated from the Penicillium sp. The α-glucosidase inhibitory effects showed that (+)-sclerotiorin (1) had significant inhibitory activity with IC50 of 3.30 μmol/L, which indicated that the secondary metabolites of endophytic fungi from the Bruguiera gymnorrhiza had the potential to be developed into new α-glucosidase inhibitors.

Key words: endophytic fungus, secondary metabolites, Bruguiera gymnorrhiza, azaphilones, α-glucosidase inhibitors, hypoglycemic

CLC Number:  R284
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