耐力运动抗非酒精性脂肪肝的形成作用及其机制

doi:10.16088/j.issn.1001-6600.2015.04.023

Abstract

Abstract: To explore and compare the effects of high intensity, vigorous intensity and moderate intensity endurance exercise on Blood Lipid, Free Radical metabolism, and its relationship with Non-Alcoholic Fatty Liver Disease (NAFLD),50 grown male SD rats were randomly divided into normal diet control group (Group C), high-fat diet control group (Group H), high-fat diet and high intensity endurance exercise group (Group Hh), high-fat diet and vigorous intensity endurance exercise group (Group Hv), high-fat diet and moderate intensity endurance exercise group (Group Hm). Except group C, the other groups were fed with high-fat diet. At the same time, the groups which were fed with high-fat diet were intervened by high, vigorous or moderately intense endurance exercise. Indexs have been observed including the Fatty Liver Disease lesions existed in rats, and detected serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST),Total Cholesterol (TC), Triglyceride (TG), Free Fatty Acid(FFA)indexs, and detected liver SOD2 mRNA and serum, liver T-Superoxide Dismutase (T-SOD), Malondialdehyde (MDA). The results show that serum ALT, AST and TC, TG, FFA levels increased significantly in rats fed with high-fat diet, and serum and liver T-SOD level decreased significantly, serum and liver MDA level increased significantly, and liver SOD2 mRNA increased significantly. In the meanwhile, Liver Index increased significantly, and the Liver Tissue under the naked eye, the Hematoxylin-Eosin (HE) put up Fatty Liver Disease morphology lesion. Compared with Group H, Group Hh, Group Hv and Group Hm mRNA increased significantly ,and the above abnormal changes for different degrees got the chain-like relief in Group Hh, Group Hv and Group Hm, and the most obvious changes occured in Group Hm. It draw a conclusion that different intensity endurance exercise can improve the abnorm of lipids metabolism, improve expression of SOD2 mRNA ,increase the activity of T-SOD, ruduce lipid peroxidation, and finatly, prevent NAFLD formation and protect liver function. Above all, moderate intensity get the best effect.

Key words: exercise intense, endurance exercise, non-alcoholic fatty liver disease, lipid metabolism

CLC Number:

G804.2

TUO Wan-liang, PENG Feng-lin. Effects on Lipid Metabolism,Antioxidant Capacity and Non-Alcoholic Fatty Liver Disease Formation in Rats with High Fat Diet[J].Journal of Guangxi Normal University(Natural Science Edition), 2015, 33(4): 144-151.

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Effects on Lipid Metabolism,Antioxidant Capacity and Non-Alcoholic Fatty Liver Disease Formation in Rats with High Fat Diet

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