Journal of Guangxi Normal University(Natural Science Edition) ›› 2012, Vol. 30 ›› Issue (2): 143-148.

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Effects of Flavones on Antioxidant Enzymes and Apoptosis in Heart of Exhauted Exercise Rats

GUO Yan-ju, PENG Feng-lin   

  1. College of Physical Education,Guangxi Normal University,GuilinGuangxi 541004,China
  • Received:2011-12-30 Online:2012-06-20 Published:2018-12-03

Abstract: Based on the study of health and male Sprague-Dauleyrats,and by setting up the experiment model of exhausted exercise after irrigatingflavones from Siraitia grosvenori Leaf(FSGL),the effects of different dose of FSGL are explored on antioxidant enzymes and Bcl-2,Bax mRNA expression in heart of exhauted exercise rats.The result indicated that the activities of SOD,CAT,GSH-PX in myocardial tissue of different doseages of FSGL were higher comparedwith exhaustion movement control group(EMG),especially the middle dose flavonesfrom Siraitia grosvenori leaf(MFSGL);the MDA concentration in EMG increasedsignificantly compared with MFSGL.The expression of Bcl-2 protein in differentdoseages of FSGL were strengthened compared with EMG,and MFSGL's expression werestrengthened significantly compared with EMG and LFSGL (P＜0.05).Meanwhile,compared with NG and MFSGL,the expression of Bax protein in EMG increased significantly (P＜0.01).The Bcl-2/Bax ratio in the different doseages of FSGL increased,especially the MFSGL and HFSGL (P＜0.01).It was clear that FSGL has a good effect to enhance the antioxidation ability of organism andto inhibit the degree of cardiomyocyte apoptosis induced by exhausted exercise.

Key words: FSGL, exhausted exercise, cardiomyocyte antioxidant enzymes, apoptosis, gene expression

CLC Number: 

  • Q593.9
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