Journal of Guangxi Normal University(Natural Science Edition) ›› 2023, Vol. 41 ›› Issue (2): 27-35.doi: 10.16088/j.issn.1001-6600.2022031701

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Research Progress of IL-31 in Itch

LI Kangliang1, QIU Caixiong1, HE Shuang1, HUANG Chunhua2, WU Guanyi1*   

  1. 1. College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning Guangxi 530299, China;
    2. College of Pharmacology, Guangxi University of Chinese Medicine, Nanning Guangxi 530299, China
  • Received:2022-03-17 Revised:2022-06-03 Online:2023-03-25 Published:2023-04-25

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Abstract: Itch is a normal symptom in many skin diseases such as atopic dermatitis, prurigo nodularis, psoriasis, and chronic urticaria. More and more data show that interleukin-31 (IL-31) plays an important role in itch. IL-31 is composed and released from CD4+ help T cell, mast cells, keratinocytes, macrophages, and dendritic cells. By activating interleukin-31 heterodimer receptors (IL-31 receptor A and tumor suppressor M receptor), itch related signals are generated. Although it has been found that IL-31 can transmit itch signals to the central nerve system directly or indirectly, mechanism of itch is not fully understood. This review summarizes the current knowledge on IL-31's gene, source, receptor, and the effect of IL-31 in pruritic diseases.

Key words: IL-31, itch, skin diseases, IL-31 receptor, keratinocytes, mast cells

CLC Number: 

  • R751
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