Journal of Guangxi Normal University(Natural Science Edition) ›› 2022, Vol. 40 ›› Issue (1): 187-194.doi: 10.16088/j.issn.1001-6600.2021060915

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Sample Size Determination for the Additive Hazards Model with Current Status Data

KONG Lingtao*, SONG Xiangjun, WANG Xiaomin   

  1. School of Statistics, Shandong University of Finance and Economics, Jinan Shandong 250014, China
  • Received:2021-06-09 Revised:2021-08-10 Online:2022-01-25 Published:2022-01-24

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Abstract: Power and sample size calculations are important and necessary parts in the design stage of a scientific study. In the failure time data analysis, the additive hazards model, which specifies that the covariates have an additive effect on the baseline risk, is one of the most popular used semiparametric models. Compared with the proportional hazards model, the additive hazards model would be more plausible in many applications, especially in the two-sample situation where the covariate takes value only 0 or 1. In this paper, a novel method is proposed for calculating power and sample size for the additive hazards model with current status data based on the Wald test. The simulation studies demonstrate that the proposed sample size formula is adequate. Moreover, a real example is presented to illustrate the application of the proposed formula.

Key words: additive hazards model, power, current status data, sample size

CLC Number: 

  • O212.6
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