Journal of Guangxi Normal University(Natural Science Edition) ›› 2015, Vol. 33 ›› Issue (1): 127-133.doi: 10.16088/j.issn.1001-6600.2015.01.021

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Epidemiology and Gene Analysis of HIV-1 in Guangxi,China

KONG Yan-lin1, ZHANG Shuai1, WANG Xue-wen1, LI He-wei1, HU Ting-ting1, JIANG Qian1,
JIANG Jiu-xi1, PAN Ding-quan2, ZHANG Zhen-kai2, LI Lin3, SUN Chang-rong3, LI Jing-yun3,
LIANG Hao4, LIANG Bing-yu4   

  1. 1.Infectious Diseases Department of Affiliated Hospital of Guilin Medical University, Guangxi Guilin 541001, China;
    2.Guilin Centre for Disease Control and Prevention, Guangxi Guilin 541001, China;
    3.Epidemiology and Microbiology Institute of Military Medical Science Academy of the PLA, Beijing 100071, China;
    4. School of Public Health of Guangxi Medical University, Guangxi Nanning 530021, China
  • Received:2014-10-12 Online:2015-03-15 Published:2018-09-17

Abstract: To determine the epidemiological situation of confirmed HIV-1 infections in Guangxi after 2008,and to understand the distribution of HIV-1 subtypes of Guangxi. An epidemiological survey was made on the HIV-1 infections confirmed after 2008. Among them, 100 come from Guilin, 102 from Laibin, and 103 from Qinzhou. HIV-1 RNA was extracted from their whole blood and amplified by RT-PCR. HIV-1 gag gene was sequenced directly from the PCR product.The results show that there are more men than women in the chosen patients, male to female ratio was 1.99:1.Patients aged ≥20 and ≤49 years old accounted for 56.72% in total, and patients aged 50 years old or older accounted for 44.62%. Farmers accounted for 50.82%.Patients with education level of junior school or below accounted for 76.39%. The patients′s proportion who were transmitted through heterosexual contact is 95.74%. 155 specimens are gained in 305 specimens(amplification rate of 50.82%), then sequence analysis showed that there were 4 HIV-1 subtypes, CRF01-AE(124 samples),B(5 samples),CRF-07BC(12 sample) and CRF-08BC(14 sample).

Key words: HIV-1, epidemiological characteristics, subtype, gag gene

CLC Number: 

  • R512.91
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