广西师范大学学报（自然科学版） ›› 2021, Vol. 39 ›› Issue (3): 131-138.doi: 10.16088/j.issn.1001-6600.2020121604

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CYP2D亚家族基因在灵长类动物中的药物代谢及进化研究

董小燕1,2, 梁秋芳1,2, 冯平1,2*   

  1. 1.珍稀濒危动植物生态与环境保护教育部重点实验室(广西师范大学), 广西 桂林 541006;
    2.广西师范大学 生命科学学院, 广西 桂林 541006
  • 收稿日期:2020-12-16 修回日期:2021-01-30 发布日期:2021-05-13
  • 通讯作者: 冯平(1986—),女,广西北海人,广西师范大学副教授,博士。E-mail: fengfengping1234@163.com
  • 基金资助:
    国家自然科学基金(32060111); 广西自然科学基金(2018GXNSFBA281010); 广西师范大学珍稀濒危动植物生态与环境保护教育部重点实验室基金(GKN.19-A-01-07)

Drug Metabolism and Evolution of CYP2D Subfamily Genes in Primates

DONG Xiaoyan1,2, LIANG Qiufang1,2, FENG Ping1,2*   

  1. 1. Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin Guangxi 541006, China;
    2. College of Life Sciences, Guangxi Normal University, Guilin Guangxi 541006, China
  • Received:2020-12-16 Revised:2021-01-30 Published:2021-05-13

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摘要： CYP2D亚家族基因普遍存在于灵长类动物中,在药物代谢方面起着重要作用,但不同地域和种族的人的CYP2D酶对同一药物的代谢效果存在差异,非人灵长类动物的CYP2D酶代谢某些药物的效果比人类的更有效。此外,在漫长的进化过程中,灵长类动物CYP2D亚家族基因之间会经历频繁的基因复制或基因丢失,导致CYP2D亚家族基因数目存在差异,但尚未确定这种差异是否与物种的亲缘关系有关。本研究对CYP2D亚家族基因在灵长类动物中的药物代谢和进化研究方面进行综述,以期为实现个体化用药和精准性治疗提供一定的理论依据,并进一步了解CYP2D亚家族基因在灵长类中的进化情况。

关键词: 灵长类动物, CYP2D亚家族基因, 药物代谢, 多态性, 进化

Abstract: CYP2D subfamily genes are commonly found in primates and play an important role in drug metabolism. However, the effect of CYP2D enzyme on the metabolism of the same drug varies in different regions and races, and the CYP2D enzyme in non-human primates metabolizes some drugs more efficiently than that in humans. In addition, during the long evolutionary process, primate CYP2D subfamily genes will experience frequent gene duplication or gene loss, leading to differences in the number of CYP2D subfamily genes, but it has not been determined whether such differences are related to the species’ genetic relationship. In this study, we reviewed the studies on drug metabolism and evolution of CYP2D subfamily genes in primates, in order to provide some theoretical basis for the realization of individualized medication and precise therapy, and further understand the evolution of CYP2D subfamily genes in primates.

Key words: CYP2D subfamily gene, primates, drug metabolism, polymorphism, evolution

中图分类号: 

  • R965
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