广西师范大学学报（自然科学版） ›› 2017, Vol. 35 ›› Issue (3): 53-62.doi: 10.16088/j.issn.1001-6600.2017.03.007

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DNA凝聚理论模拟研究

张敏1, 2, 辜凌云1, 2, 周勋1*, 刘艳辉2*   

  1. 1.贵州师范大学物理与电子科学学院,贵州贵阳550025;
    2.贵州大学物理学院,贵州贵阳550025
  • 出版日期:2017-07-25 发布日期:2018-07-25
  • 通讯作者: 周勋(1966—),男,重庆人,贵州师范大学教授,博士。E-mail:hbkfy@gznu.edu.cn
    刘艳辉(1978—),男,吉林四平人,贵州大学教授,博士。E-mail:ionazati@itp.ac.cn
  • 基金资助:
    国家自然科学基金(11047022,11204045,11464004,31360215);贵州大学实验室开放项目(201611);中国博士后面上资助项目(2014M562341);贵州大学青年教师基金(201311);贵州省科学技术基金( 黔科通J合[2006]2004);贵州省优秀科技人才省长基金 (黔省专合字(2009)114)

Simulation Study of DNA Condensation Theory

ZHANG Min1,2,GU Lingyun1,2, ZHOU Xun1*,LIU Yanhui2*   

  1. 1.School of Physics and Electronic Science,Guizhou Normal University,Guiyang Guizhou 550025,China;
    2.College of Physics,Guizhou University,Guiyang Guizhou 550025,China
  • Online:2017-07-25 Published:2018-07-25

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摘要： 为进一步揭示DNA凝聚物理机制,基于凝聚反离子强关联性质,本文建立DNA分子凝聚强关联模型并利用Monte Carlo 模拟方法研究DNA分子凝聚的相关性质。凝聚过程中,凝聚构象回转半径出现“台阶式”变化,DNA凝聚过程呈现不连续性;片段自相关定量用来表征DNA凝聚构象中成环数目。凝聚相图表明,DNA凝聚构象大多数为复杂花样结构,凝聚成环的概率较小。凝聚反离子强关联模型较好地揭示了DNA凝聚机制。

关键词: 凝聚反离子, 强关联, DNA凝聚, Monte Carlo 模拟, 回转半径

Abstract: In order to identify the mechanism of DNA condensation further, a strong correlation model is established based on the strong correlation of condensed counterios and Monte Carlo simulation is employed to study the properties of DNA condensation. During the condensation process, gyration radii of condensed conformation appear step-wise manner indicating the discontinuousness of process of DNA condensation. Autocorrelation of the segment reflects the number of loop structure in the condensed conformation, the condensed phase diagram shows the complexity of the condensed conformation, the majority of condensed conformations take on the complex flower structure, and in comparison with flower structure, the occurrence rate of the toroidal structure is small. All the results mentioned above show strong highlight into the mechanism of DNA condensation.

Key words: condensed balanced ions, strong correlation, DNA condensation, Monte Carlo simulation, gyration radius

中图分类号: 

  • Q61
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