Journal of Guangxi Normal University(Natural Science Edition) ›› 2011, Vol. 29 ›› Issue (1): 47-51.

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Anti-HCMV Effect andIts Mechanism of Water Extract from Cordvceps sinensis

CAI Hao-bin1,2, ZHANG Xuan1,2,3, WANG Mao-shui4, ZHENG Zhong-sheng5, QIN Xue4, YANG Yan-hua2, SHEN Xing-can1,3   

  1. 1.Ministry of Education Key Laboratory for the Chemistry andMolecular Engineering of Medicinal Resources,Guangxi Normal University,Guilin Guangxi 541004,China;
    2.Institute of Guilin Immunetech,Guilin Guangxi 541001,China;
    3.College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;
    4.The First Attachment Hospital of Guangxi Medical University,Nanning Guangxi 530027,China;
    5.Hong Kong Huaian Tienchi Limited Company,Hong Kong 999077,China
  • Received:2010-09-07 Published:2018-11-16

Abstract: The anti-HCMV effect and its potential mechanism ofthe water extract from Cordyceps sinensis is investigated.Cytopathic effect(CPE) method is utilized to examine its toxicity to human fore-skin fibroblasts (HFFs) and the anti-HCMV effect in vitro of the water extract.Moreover,western-bolt is used to investigate the mechanism of anti-HCMV effect of the water extract.The results show that the water extract can inhibit HCMV replication effectively at the concentration of 0.3 g·L-1.In HCMV-infected cells,the expression of immediate-early protein IE1、IE2 and early protein UL84 can be inhibited to a large degree when treating with the water extract.

Key words: water extract from Cordyceps sinensis, human cytomeglovirus(HCMV), human foreskin fibroblast (HFF), cytopathic effect (CPE), anti-virusherb, western boltting

CLC Number: 

  • TP391.41
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