CYP2D亚家族基因及其进化机制研究进展

doi:10.16088/j.issn.1001-6600.2020122201

Abstract

Abstract: CYP2D enzyme plays an important role in drug metabolism and the detoxification of toxic substances. Knowing and understanding the adaptive evolution of CYP2D subfamily genes helps to understand the mechanism of CYP2D enzymes on toxic substances. Research has shown that CYP2D subfamily genes have lineage-specific expansion in the evolutionary process. In addition, gene duplication, gene conversion, and selective pressure had a certain influence on the evolution of genes, but the effect varied with different lineages. In this paper, the structure, function and evolutionary mechanism of CYP2D subfamily genes were reviewed, in order to provide a theoretical basis for understanding the adaptive evolution of CYP2D subfamily genes.

Key words: cytochrome P450, CYP2D genes, gene duplication, gene conversion, selective pressure

CLC Number:

LIANG Qiufang, DONG Xiaoyan, FENG Ping. Advanced in CYP2D Subfamily Genes and Evolutionary Mechanisms[J].Journal of Guangxi Normal University(Natural Science Edition), 2021, 39(5): 58-63.

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Advanced in CYP2D Subfamily Genes and Evolutionary Mechanisms

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