Journal of Guangxi Normal University(Natural Science Edition) ›› 2021, Vol. 39 ›› Issue (5): 1-29.doi: 10.16088/j.issn.1001-6600.2020110903

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Research Progress of New C21-Steroids in Medicinal Plant of Asclepiadaceae (Ⅰ)

ZHAN Xin, CHEN Lijing, LIAO Guangfeng, LI Bing, LU Rumei*   

  1. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China
  • Received:2020-11-09 Revised:2021-01-16 Online:2021-09-25 Published:2021-10-19

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Abstract: C21-steroids is a steroid derivative with 21 carbon atoms in the parent nucleus, and it is a derivative of pregnanes or its isomer. It has many pharmacological activities such as anti-tumor, anti-inflammation and analgesia, anti-fertility, anti-depression and immune regulation, etc. The plant of the family Asclepiadaceae is one of the main sources of natural C21-steroids. According to the statistics of relevant literature, 624 new C21-steroidal compounds were isolated and identified from the medicinal plant of Asclepiadaceae in the past 2 decades, including 9 different skeleton types. In this paper, the distribution, structural characteristics and pharmacological activities of C21-steroids in plants of Asclepiadaceae since 2000s were summarized in three parts, in order to provide references for the further research, development and utilization of C21-steroids, and to provide scientific basis for exploring the medicinal value and therapeutic basis of the plants of Asclepiadaceae. At the beginning of this paper, the distribution, structural characteristics, physicochemical properties and spectra of the prene-type C21-steroids in plants of Asclepiadaceae were reviewed.

Key words: Asclepiadaceae, C21-steroids, distribution, structural characteristics, spectral characteristics

CLC Number: 

  • O629.2
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[3] LIU Wei, WANG Hao, FANG Bao-fu. RoboCup-Rescue Decision Making Process Based on Binary Particle Swarm Optimization[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(2): 130 -133 .
[4] LI Zhi, PANG Liu, LIU Guo-yuan, YANG Zhi-shang. A Model-Driven Software Requirements Analysis Method and Its Technical Support[J]. Journal of Guangxi Normal University(Natural Science Edition), 2013, 31(2): 19 -26 .
[5] SONG Shu-xiang. Synthesis Design Method of Odd-nth-order Current Mode All-passFilter[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(3): 9 -13 .
[6] ZHANG Liu-sheng, PAN Cheng-xue, LI Li, SU Gui-fa, HUANG Wan-yun, QIN Jiang-ke, TANG Huang. Synthesis and Crystal Structure of Conformationally ConstrainedDipeptide with 1-Aminocyclopropanecarboxylic Acid Residue[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(3): 37 -42 .
[7] MENG Zu-qiang, XU Ke, ZHOU Shi-quan. Maximum Distribution Reduct and Its Calculation Method in IncompleteInconsistent Decision Systems[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(3): 89 -93 .
[8] WEI Yu-ming, WANG Yong, TANG Yan-qiu, FAN Jiang-hua. Existence and Uniqueness of Solutions for Delay Boundary Value Problems with p-Laplacian on Infinite Intervals[J]. Journal of Guangxi Normal University(Natural Science Edition), 2012, 30(2): 48 -53 .
[9] LIN Song, YIN Changming. Asymptotic Properties of Estimation of Penalized Generalized Estimating Equations for Two Stage Logit Models[J]. Journal of Guangxi Normal University(Natural Science Edition), 2019, 37(2): 126 -130 .
[10] WANG Xun, LI Tinghui, PAN Xiao, TIAN Yu. Image Segmentation Method Based on Improved Fuzzy C-means Clustering and Otsu Maximum Variance[J]. Journal of Guangxi Normal University(Natural Science Edition), 2019, 37(4): 68 -73 .
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