Journal of Guangxi Normal University(Natural Science Edition) ›› 2018, Vol. 36 ›› Issue (1): 149-157.doi: 10.16088/j.issn.1001-6600.2018.01.022

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Reverse Projection of the Central Nucleus of Amygdala in Mice

XIE Jing1,2,TANG He3,4,LIN Wanhua5,SUN Huaying1,WU Guisheng1,HE Xiaoming1, DENG Ke1,2,LUO Huairong1*   

  1. 1.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany, Chinese Academy of Sciences,Kunming Yunnan 650201,China;
    2. College of Life Science, University of Chinese Academy of Sciences,Beijing 100039,China;
    3. Henan Provincial People’s Hospital, Zhengzhou Henan 450003, China;
    4. Henan Institute of Ophthalmology, Zhengzhou Henan 450003,China;
    5. College of Life Science, Guangxi Normal University,Guilin Guangxi 541006,China
  • Received:2017-05-03 Online:2018-01-20 Published:2018-07-17

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Abstract: The amygdala is an important part of the limbic system that is associated with mental disorders. The central nucleus and basal nucleus of amygdala both play vital role in condition fear,motivational reward,drug addiction and temporal lobe epilepsy. The fiber connection is the physiological basis for their neural function. Nowadays,the neurotropic viruses have become an effective tool for the investigation of the neuroconncetion. A new type of rabies virus(RV), being a reverse virus that cannot cross synapse, was used in this experiment, which ensures the specificity of the projection in our experimental results. The virus was injected into the central nucleus of amygdala. After 7 days,the brain slice was observed and many brain areas were labeled, including striatum,basal nucleus of amygdala,lateral nucleus of amygdala,interstitial nucleus of the posterior limb of the anterior commissure medial part,anterior amygdaloid area dorsal part and other part of amygdala,cortical regions et al. Our results show that the central nucleus of amygdala receives a wide range of direct nerve fibers projections from many brain regions which may indicate physiological function of amygdala.

Key words: central nucleus of amygdala, reverse projection, RV virus, neurotropic virus

CLC Number: 

  • Q422
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