Journal of Guangxi Normal University(Natural Science Edition) ›› 2017, Vol. 35 ›› Issue (2): 101-107.doi: 10.16088/j.issn.1001-6600.2017.02.015

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Interaction between Carbon Quantum Dots and Human Serum Albumin

ZOU Hua,LIU Huarong*,MEI Ping   

  1. School of Chemical and Environmental Engineering, Yangtze University, Jingzhou Hubei 434023, China
  • Online:2017-07-25 Published:2018-07-25

Abstract: Carbon quantum dots(CQDs)was synthesized from citric acid. The structures and optical properties of the obtained CQDs were characterized by UV-vis absorption spectroscopy, photolumine- scence spectroscopy and transmission electron microscope(TEM). The interaction between human serum albumin(HSA)and CQDs under physiological conditions was also investigated. The investigation was carried out with the use of uorescence spectroscopy, circular dichroism(CD)spectra and UV-vis spectroscopy. The results of fluorescence quenching and UV-vis absorption spectra experiments indicated the formation of the complex of HSA and CQDs. The hydrogen bond and Van der Waals’ force played predominant roles in the interaction process. Furthermore, it proved that CQDs could induce the conformational change of HSA. The research results provided a lot of important theoretic information for the biosafty evaluation of CQDs.

Key words: carbon quantum dots, citric acid, human serum albumin(HSA), fluorescence spectra, circular dichroism spectra, UV-vis absorbance spectra

CLC Number: 

  • Q512.1
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