口腔鳞状细胞癌中KLF6、p21和c-Jun的表达

广西师范大学学报（自然科学版） ›› 2011, Vol. 29 ›› Issue (2): 94-98.

口腔鳞状细胞癌中KLF6、p21和c-Jun的表达

黄健¹, 王国华², 侯巧燕³, 侯菊花¹

1.桂林医学院生物技术学院,广西桂林541004;
2.桂林医学院附属医院口腔科,广西桂林541001;
3.桂林医学院附属医院病理科,广西桂林541001

收稿日期:2011-03-21 发布日期:2018-11-19
通讯作者: 黄健(1966—),女,广西荔浦人,桂林医学院教授,硕士。E-mail:huangjian730@yahoo.com.cn
基金资助:
广西自然科学基金资助项目(桂科自0499019);国家自然科学基金资助项目(30960498)

Expression of KLF6,p21 and c-Jun in Oral Squamous Cell Carcinoma

HUANG Jian¹, WANG Guo-hua², HOU Qiao-yan³, HOU Ju-hua¹

1.College of Biotechnology,Guilin Medical University,Guilin Guangxi 541004,China;
2.Department of Stomatology,Affiliated Hospital,Guilin Medical University,Guilin Guangxi 541001,China;
3.Pathology,Affiliated Hospital,Guilin Medical University,Guilin Guangxi 541001,China

Received:2011-03-21 Published:2018-11-19

摘要/Abstract

摘要： 为探讨口腔癌组织中KLF6、p21和c-Jun的表达及意义,采用免疫组化技术检测198例口腔癌、49例口腔良性肿瘤中KLF6、p21和c-Jun的表达,以56例口腔正常组织作对照。结果显示:正常对照组、良性及恶性肿瘤KLF6的表达分别为91.07%(51/56)、83.67%(41/49)、62.12%(123/198),三组间阳性表达有显著性差异(P＜0.05);KLF6在肿瘤直径＞2 cm组和中、低分化组中的阳性表达显著低于肿瘤直径≤2 cm组及高分化组(P＜0.01);p21在恶性肿瘤中阳性表达81.82%(162/198)显著低于正常组的85.71%(48/56)(P＜0.05);c-Jun在正常对照组、良性肿瘤及恶性肿瘤的表达分别为8.93%(5/56)、10.20%(5/49)、46.97%(93/198),三组间阳性表达有显著性差异(P＜0.05)。恶性肿瘤中KLF6基因核表达缺失或减弱与p21表达下调显著相关(P＜0.01),恶性肿瘤中KLF6浆表达增加与p21表达下调显著相关(P＜0.01)。恶性肿瘤中KLF6核表达缺失或减弱与c-Jun阳性表达增加显著相关(P＜0.01)。可见,KLF6、p21和c-Jun三者表达异常与口腔癌的发生发展密切相关,其分子机制值得深入研究。

关键词: KLF6, p21, c-Jun, 口腔鳞状细胞癌

Abstract: To assess the expression of KLF6,p21 and c-Jun in oral squamous cell carcinoma,the expression of KLF6,p21 and c-Jun were detected by immunohistochemistry among 198 cases of cancerous tissue,49 cases of hyperplastic tissue,compared with 56 controls of normal tissue.The expression of KLF6 inthe group of normal,hyperplastic and cancerous tissue were 91.07%(51/56),83.67%(41/49),62.12%(123/198),respectively.There were significant differences amongthe three groups (P＜0.05).The positive expression of KLF6 in the group oftumor＞2 cm and moderate differentiated and poorly differentiated were significantly lower than that in the group with tumor≤2 cm and high differentiated (P＜0.01).The positive expression of p21 in cancerous tissue of 81.82%(162/198)was significantly lower than that in normal tissue with 85.71%(48/56) (P＜0.05).The expression of c-Jun in the group of normal,hyperplastic and canceroustissue were 8.93%(5/56),10.20%(5/49),46.97%(93/198),respectively.There were significant differences among the three groups (P＜0.05).The deletion or reducing of KLF6 expression in nucleus and the increasing of KLF6 expression in cytoplasm were significantly correlated with the downregulation of p21 expression in the cancerous tissues (P＜0.05).The deletion or reducing of KLF6 expression innucleus was significantly correlated with the increasing of c-Jun expression in the cancerous tissues (P＜0.01).The results indicate that the abnormal expression of KLF6,p21 and c-Jun may involve in the development of the oral squamous cell carcinoma.Further research should be done to find out the mechanism andcorrelativity.

Key words: KLF6, p21, c-Jun, oral squamous cell carcinoma

中图分类号:

R739.8

黄健, 王国华, 侯巧燕, 侯菊花. 口腔鳞状细胞癌中KLF6、p21和c-Jun的表达[J]. 广西师范大学学报（自然科学版）, 2011, 29(2): 94-98.

HUANG Jian, WANG Guo-hua, HOU Qiao-yan, HOU Ju-hua. Expression of KLF6,p21 and c-Jun in Oral Squamous Cell Carcinoma[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(2): 94-98.

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