耐力运动抗动脉粥样硬化的形成作用及其机制

摘要/Abstract

摘要： 为比较并探讨不同强度耐力运动对较短周期高脂饮食大鼠动脉粥样硬化(AS)形成的干预作用,将成年雄性SD大鼠50只,随机分为正常对照组(N组)与高脂饲料组 (H组)、大强度运动组(Hh组)、中等强度运动组(Hm组) 、小强度运动组 (Hl组):观察各组大鼠胸主动脉有无AS病变,分析AS发病率与AS斑块面积;检测血清TC、TG、LDL-C、HDL-C及SOD、MDA与ox-LDL指标,结果发现:6周高脂饮食喂养引起大鼠血清TC、LDL-C、MDA及ox-LDL水平显著升高,AS发病率显著升高、发病程度为轻度;与H组相比,Hh组、Hm组及Hl组TC、LDL-C水平显著下降,此外Hl组HDL-C浓度显著升高;Hh组、Hm组、Hl组MDA含量均显著低于H组,但Hl组SOD活性无显著提高;Hl组ox-LDL及AS病变面积百分比显著低于H组。可见6周高脂饮食引起大鼠血脂异常、自由基代谢水平显著升高,从而引起LDL氧化修饰反应增加,诱发轻度AS病变;小强度运动似乎调血脂作用最佳,从而使控制LDL氧化修饰反应的效应放大而加强了抗AS形成作用。

关键词: 运动强度, 动脉粥样硬化, 氧化修饰, 保护

Abstract: To explore the effects and its mechanism of different intensity exercise on atherosclerosis (AS) formation in Rats fed with high fat diet for short cycle,50 rown male SD rats were randomly divided into normal control group (group N),high fat diet group (group H),high intensity exercise group (group Hh),moderate intensity exercise group (group Hm), and low intensity exercise group (group Hl). Observe whether the thoracic aorta AS lesions existed in rats, analyze AS incidence and AS plaque area, and detect serum TC,TG,LDL-C, HDL-C and SOD, MDA and ox-LDL indexs.The results show that serum TC, LDL-C,MDA and ox-LDL levels increased significantly in rats fed with high fat diet for six weeks,and AS incidence increased significantly, comparing with group H. TC and LDL-C levels decreased significantly in group Hh,group Hm and group Hl,HDL-C level increased significantly in group Hl.In Group Hh, group Hm, group Hl,MDA levels were significantly lower than those of group H,but SOD activity was not increased apparently in group Hl.In group Hl,ox-LDL level and AS plaque area percentage were significantly lower than that of group H. It draw a conclusion that high fat diet for 6 weeks causing dyslipidemia,free radical metabolism increased,and the increase in LDL oxidation modification led to mild AS. To regulating blood fat, effect of low intensity exercise is the best,so low intensity exercise can control the reaction of LDL oxidative modification and strengthen the role of anti AS formation.

Key words: exercise intensity, atherosclerosis, oxidative modification, protection

中图分类号:

Q593.9

许思毛, 莫伟彬, 刘卫国. 耐力运动抗动脉粥样硬化的形成作用及其机制[J]. 广西师范大学学报（自然科学版）, 2014, 32(3): 125-132.

XU Si-mao, MO Wei-bin, LIU Wei-guo. Effects and Its Mechanism of Endurance Exercise on Atherosclerosis Formation Fed with High Fat Diet[J]. Journal of Guangxi Normal University(Natural Science Edition), 2014, 32(3): 125-132.

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